凝血系统相关基因突变及表达异常与高血凝  

Mutation and Unusual Expression of Clotting System-related Genes and Hypercoagulability

作　　者：赵玉华[1] 刘秉文[1] 

机构地区：[1]四川大学华西基础医学与法医学院生物化学与分子生物学教研室,成都610041

出　　处：《生理科学进展》2003年第4期324-328,共5页Progress in Physiological Sciences

基　　金：国家重点基础研究发展规划项目"973"(G2 0 0 0 0 5 6 90 0 )资助课题

摘　　要：高血凝是动脉粥样硬化 (As)的危险因子 ,在As的发展中具有重要作用。凝血系统、抗凝系统、纤溶系统及其它相关基因的突变及表达异常导致高血凝的产生。凝血系统的凝血因子Ⅴ基因、凝血酶原基因、组织因子基因 ,抗凝系统的血栓调节蛋白基因、抗凝血酶Ⅲ基因 ,纤溶系统的纤溶酶原激活物抑制剂 1基因 ,均与高血凝密切相关。Hypercoagulability is a risk factor for atherosclerosis (As) and plays an important role in the development of As. Hypercoagulability results from mutation and unusual expression of clotting system related genes, anticlotting system related genes, fibrinolytic system related genes and other related genes. Factor V gene, prothrombin gene and tissue factor gene in clotting system, thrombomodulin gene and antithrombin III in anticlotting system, plasminogen activator inhibitor 1 gene in fibrinolytic system, are related with hypercoagulability tightly.

关 键 词：高血凝 基因突变 凝血系统 抗凝系统 纤溶系统 

分 类 号：R559[医药卫生—血液循环系统疾病]