血色病病人肝内铁沉积点的超微结构研究  

ULTRASTRUCTURAL STUDY OF IRON DEPOSITION IN LIVER OF HEMOCHROMATOSIS PATIENT

作　　者：徐文伯[1] 钟慈声[1] 凌治萍[1] 陆孝禹[2] 刘朝 

机构地区：[1]上海医科大学细胞超微结构研究室 [2]华东医院病理科 [3]宝山钢铁总厂电镜室

出　　处：《解剖学杂志》1989年第3期157-160,241,共4页Chinese Journal of Anatomy

摘　　要：本文运用超显微技术和电镜X射线显微分析技术对血色病病人肝内铁沉积点进行研究。发现本例特发性血色病病人肝细胞内,含有许多具有无定形结构、脂质和膜样结构的溶酶体,对其进行X射线元素分析时,荧光屏上没有显出FeK_2峰。血窦内皮细胞和枯否氏细胞内也含有深染的颗粒‘大小似溶酶体、单层膜包裹,其内含电子密度高的微粒,有的颗粒内微粒密集,彼此轮廓无法分辨,有的微粒分布稀疏,轮廓清楚,直径约10nm,对其进行X射线元素分析时荧光屏上能量为6.39Kev处有明显的FeKα峰。本工作表明此病人肝细胞的溶酶体中并不含有明显的铁,而血窦内皮细胞、枯否氏细胞里的深染颗粒是铁的主要沉积点,其形态与含铁血黄素小体相似,而与一般次级溶酶体不同。This report represents observations on the location of irom deposits in the liver of hemochromatosis patient by ultrastructural and X-ray microanalytic studies. It was found that. there were many lysosomes in the hepatoeytes of the patient. When the electron beam was focusedon the lysosomes. there was no Fe Ka peak in the spectrum. In the endothelial cells and Kupffer cells of sinusoid, there were lysosomes like granules with an envelope and many electron dense particles of 10nm diameter in them. When the electron beam was focused on them,aFe Ka peak appeared in the spectrum. This work shows that lysosomes in the hepatocytes of the hemochromatosis patient contain no detectable iron, but the dense lysosomes like granules in the endothelial cells and Kupffer cells of sinusoid contain iron. They are like morphologically siderosomes and different fron the secondary lysosomes.

关 键 词：血色病 铁沉积点 超微结构 

分 类 号：R559.02[医药卫生—血液循环系统疾病]