大鼠急性脑缺血再灌注损伤中康络素对谷氨酸抑制作用的实验研究  

Experiment of inhibition of Cronassial to Glu during ischemia reperfusion of rat

作　　者：刘松岩[1] 赵晴[1] 王晶 

机构地区：[1]吉林大学中日联谊医院神经内科,吉林 长春 130031 [2]梨树县第一医院神经内科

出　　处：《白求恩医科大学学报》2001年第1期37-38,共2页Journal of Norman Bethune University of Medical Science

摘　　要：目的 :探讨康络素对脑缺血再灌注损伤的保护作用。方法 :采用 Pulsinelli的四血管闭塞法制备大鼠急性脑缺血再灌注模型 ,利用高压液相色谱法观察脑缺血再灌注期间谷氨酸、γ-氨基丁酸含量变化 ,通过图象分析仪测定神经元的面数密度及康络素对以上指标的影响。结果 :谷氨酸、γ-氨基丁酸含量于缺血后明显升高 ,再灌注后降低 ,康络素可降低谷氨酸含量 ,与盐水对照组相比差异显著 (P<0 .0 1) ,同时增加神经元面数密度。结论 :康络素通过抑制谷氨酸释放可减轻脑缺血再灌注期间脑组织损伤。? Objective:To study the Cronassial′protective effect on brain tissue during ischemia reperfusion.Methods:The rat cerebral ischemia reperfusion model was prepared by four vessel occulasion method.The Glu,GABA content in hippocampus during cerebral ischemia reperfusion was observed by high press liquid phase method.Results:Glu,GABA content increased during ischemia and decreased during reperfusion. Cronassial could obviously decrease the Glu content and increase neuron density.Conclusion:Cronassial can inhibit Glu and protect brain tissue during cerebral ischemia reperfusion. 〔

关 键 词：大鼠 急性脑缺血 再灌注损伤 康络素 谷氨酸 抑制作用 实验 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]