国人胆囊结石的形态结构特征  

Structure pattern of gallbladder stone in Chinese

作　　者：吴杰[1] 杨海珉[1] 李静仪[2] 宋一德 刘刚[3] 

机构地区：[1]昆明医学院物理数学教研室,云南省昆明市650031 [2]云南师范大学物理系,云南省昆明市650092 [3]云南师范大学分析测试中心,云南省昆明市650092

出　　处：《世界华人消化杂志》2003年第10期1558-1562,共5页World Chinese Journal of Digestology

基　　金：国家自然科学基金;No.39960024;云南省自然科学基金;No.1999C0064M;云南省教委科学研究基金;No.9912073

摘　　要：目的:探讨胆囊结石中晶体物质的组成、形态和结构及其在胆囊结石形成与生长过程中的作用。方法:在单盲的条件下,分别用偏光显微镜、扫描电镜和X射线衍射仪对35例人体胆囊结石的晶体结构、剖面超微结构及晶体组成进行观察研究。结果:颗粒状胆囊结石尽管其外观和剖面的形状结构各不相同,但都以结晶矿物质为主,其主要成分为胆固醇晶体。晶体的干涉色级为二级蓝绿,双折射率△n=0.022-0.025。胆石中的晶体以密集分布的微晶体和微晶体集合体的形式存在,其间隙被非晶物质填充,泥沙状结石以非晶态物质为主,其主要成分是胆色素和胆色素盐,属胆色素结石。结论:人体胆囊结石是一种特殊的生物晶体。胆囊内多变的结晶环境并不支持胆固醇晶体的完整发育,胆固醇晶体构成了颗粒状胆囊结石的基本架构,非晶物质的沉积促使了结石的进一步生长。AIM: To investigate the compositions and structure of crystal materials in gallbladder stone and their roles in the formation and growth of gallbladder stone. METHODS: The crystal structure, section ultramicroscopic structure and crystal compositions were observed with polarizing microscope, SEM and X-ray diffraction analysis respectively in single-blind trial. RESULTS: Varied as it was in external and profile structures, all kinds of particulate bilestones were chiefly composed of crystalline cholesterol. The interference color order of these crystals was the second blue-green, the double re- fractive index △ n=0.022-0.025. These crystals in the bilestone took the form of many microcrystals or polymer- microcrystals, and the holes among microcrystals were filled with some noncrystalline substance. Tho major com- ponent of sandstone was bile pigment and bile pigment salt, mainly noncrystalline substance. Sandstone belonged to bile pigments stone. CONCLUSION: Gallbladder stone is a special biological crystal, mainly composed of cholesterol. Although change- able crystallization environment in gallbladder does not favor the arowth of cholesterol crystals, cholesterol crystals form the basic structure of particulate gallbladder stone, deposition of noncrystalline substance facilitates further growth of bilestone.

关 键 词：胆囊结石 胆固醇晶体 超微结构 偏光显微镜 描电镜 X射线衍射仪 

分 类 号：R575.62[医药卫生—消化系统]