α1b、α2b型干扰素滴眼剂治疗单纯疱疹病毒性角膜炎临床对比研究  

The comparison of of IFNα1b and IFNα2b on the treatment of keratitis of herpes simplex Virus

作　　者：张晓峰[1] 李龙标[1] 张济明[1] 姚静艳[1] 杨吉成[2] 盛伟华[2] 

机构地区：[1]苏州大学附属第一医院眼科,215006 [2]苏州大学细胞与分子生物学教研室

出　　处：《中国实用眼科杂志》2003年第11期828-829,共2页Chinese Journal of Practical Ophthalmology

摘　　要：目的 :对比研究α1b、α2b干扰素治疗单纯疱疹病毒角膜炎的疗效。方法 :46例单纯疱疹病毒性角膜炎患者随机分为两组 ,A组 ( 2 9例 2 9眼 )滴IFNα1b眼液 (滴宁眼液 ) ,B组 ( 17例 17眼 )滴IFNα2b眼液 (安达芬 )。结果 :角膜溃疡平均愈合时间 :A组 12 87± 2 12天 ,B组 9 45± 3 0 4天 (P <0 0 1)。结论 :IFNα2b治疗单纯疱疹病毒性角膜炎与IFNα1b相比疗效略好。Objective:To study the results of IFNα1b and IFNα2b on the treatment of Herpes Simplex Virus keratitis.(HSK) Methods:46 cases of HSV keratitis were divided into two parts,A group (29 eyes of 29 cases) was given IFNα1b,B (17 cases,17eyes) was given IFN α 2b. Results:The average period of cure of A set was 12.87±2.12 days and B set was 9.45±3.04 days(P<0.01). Conclusions:IFNα2b has good curative effect on HSK.The curative effect of IFNα2b is slightly better than IFNα1b.

关 键 词：α1b型干扰素滴眼剂 α2b型干扰素滴眼剂 药物治疗 单纯疱疹病毒性角膜炎 安达芬 

分 类 号：R772.21[医药卫生—眼科] R752.11[医药卫生—临床医学]