伤寒杆菌70KD热休克蛋白的抗肿瘤作用  

The Anti-tumor Function of 70KD Heat Shock Protein of Salmonella Typhi

作　　者：王笑虹[1] 王鸿[1] 冯仲珉[2] 况红星 

机构地区：[1]大连大学医学院,辽宁大连11662 [2]大连医科大学第二附属医院,辽宁大连116023 [3]淄博市周村区人民医院,山东淄博255300

出　　处：《大连大学学报》1999年第6期80-82,共3页Journal of Dalian University

摘　　要：纯化伤寒杆菌HSP70，观察其对小鼠S180肿瘤细胞的抑制作用，对荷瘤小鼠连续皮下注射伤寒杆菌HSP70，每只小鼠每天注射100μ／mL，的伤寒杆菌HSP70．5mL，每天一次．9天后处死小鼠，剥离肿瘤，分别称量实验组与对照组小鼠肿瘤的重量．结果表明，伤寒杆菌HSP70能明显抑制小鼠S180肿瘤细胞在小鼠体内的生长．The suppressive effect of HSP70 of Salmonella Typhi has been, observed on mice with S180 tumor. The HSP70 of Salmonella Typhi has been injected subcutaneously continuously into the mice with tumor. Each mouse has been injected with 0.5mL HSP70 of 100μg/mL daily. Nine days later, the mice have been killed, and the weight of tumor has been weighed. The result shows that the HSP70 of Salmonella Typhi can evidently suppress the groWth of S180 tumor in vitro.

关 键 词：伤寒杆菌 热休克蛋白 肿瘤细胞 免疫原性 抗肿瘤作用 

分 类 号：R730[医药卫生—肿瘤]