BCEF0083对慢性应激抑郁模型大鼠睡眠及行为的影响  

Effect of BCEF0083 on sleep-wakefulness cycle and behaviour in chronic unpredictable stress model of depression in rats

作　　者：程燕[1] 明亮[1] 周兰兰[1] 章功良[2] Jidong Fang 

机构地区：[1]安徽医科大学药理学教研室,合肥,230032 [2]安徽医科大学生理学教研室,合肥,230032

出　　处：《中国药理学通报》2003年第11期1307-1310,共4页Chinese Pharmacological Bulletin

基　　金：安徽省科技厅自然科学基金资助课题 ;No 44 415;安徽省教育厅科学基金资助课题 ;No 2 0 0 1KJ13 0

摘　　要：目的　研究一种白僵菌代谢产物 (BCEF0 0 83)对慢性应激抑郁模型大鼠行为及睡眠觉醒周期的影响。方法　采用慢性不可预见性应激造成大鼠抑郁模型 ,运用脑立体定位、多导睡眠描记 (PSG)、开野实验 (open field)行为测定观察BCEF0 0 83对慢性应激抑郁模型大鼠睡眠觉醒周期及行为的影响。结果　BCEF0 0 83可增加慢性应激大鼠open field行为中的水平及垂直活动得分 ,逆转慢性应激造成的大鼠REMS睡眠增加。结论　BCEF0 0AIM To study the effect of bioactive compounds from entomogenous fungi (BCEF0083) on sleep-wakefulness cycle and behaviour in chronic unpredictable stress model of depression in rats. METHODS The effect of BCEF0083 on sleep-wakefulness cycle and behaviour was examined in the chronic unpredictable stress model of depression in rats. Stereotaxic and polysomnography were used to record the sleep-wakefulness cycle. The behaviour of rats was tested in the open field. RESULTS BCEF0083 increased ambulation and rearing score of chronic unpredictable stressed rats in the open field. BCEF0083 attenuated REMS percent and latency in chronic stressed rats obviously. CONCLUSION BCEF0083 can ameliate sleep-wakefulness cycle and behaviour in chronic unpredictable stress model of depression in rats.

关 键 词：抑郁症 行为 多导睡眠描记 睡眠 大鼠 BCEF0083 

分 类 号：R-332[医药卫生] R338.63