共同性斜视眼外肌的电镜观察  

Electron microscopic observertion of extraocular muscle in comitant strabismus

作　　者：郑绍斌[1] 林发森[1] 邱芳芳 陈振斌[3] 徐国兴[1] 马少青[1] 周琳瑛[3] 韩晓丽 刘小燕 

机构地区：[1]福建省眼科研究所,350005 [2]福建省医科大学附属第一医院 [3]福建医科大学电镜室

出　　处：《中国斜视与小儿眼科杂志》2003年第3期117-118,T002,共3页Chinese Journal of Strabismus & Pediatric Ophthalmology

摘　　要：目的　通过对 76例共同性内、外斜视眼外肌及 7例正常眼外肌的电镜观察 ,探讨斜视发病机制。方法　应用电子技术对 3 4例共同性内斜视眼、 42例共同性外斜视眼及 7例非斜视行眼球摘除眼的眼外肌进行超微结构观察分析。结果　非斜视组肌细胞正常 ,肌丝 ,肌节排列整齐 ,方向一致 ,Z带清晰 ,线粒体分布正常 ,未见坏死 ,斜视患者弱侧眼外肌部分肌纤维不同程度萎缩 ,变性 ,肌原纤维稀疏 ,有的肌原纤维排列方向紊乱 ,线粒体增多 ,肌质网扩张 ;有 1例肌纤维坏死 ,结构消失 ,代之以纤维组织 ;有些有髓神经髓鞘结构破坏。结论　提示共同性斜视眼外肌的确产生超微结构改变。Electron microscopic observertion of extraocular muscle in comitant strabismus. Zheng Shao-bin, Lin Fa-sen, Qiu Fang-fang, et al. Fujian Eye Institute, Fuzhou 350005 Objective To investigate the mechanism for comitant strabismus by observing extraocular muscle with transmission electron microscope in 56 specimens of esotropia and exotropia and 7 normal ocular alignment. Method The pathological ultrastructure of extraocular muscle was observed with electron technology and analyzed in comitant esotropia of 23 cases and comitant exotropia of 33 cases and 7 normal ocular alignment. Result The muscle fibers of weaker ocular muscle atrophied or degenerated to different extent and myofibrils became thin. Arrangmental direction of myofibrils became disorderly. Mitochondria were many. Sarcoplasmic reticulum was enlarged. Levels of myelin sheath were damaged in some medullated fibers of myelin sheath. The pathologic change became more obviously with the prolongation of the course. Parts of stronger ocular muscle became slight degeneration. Conclusion Pathological changes existed in ocular muscle ultrastructure to different extent. The pathologic change becomes more obviously with the prolongation of the course.

关 键 词：共同性斜视 眼外肌 电镜 发病机制 

分 类 号：R777.41[医药卫生—眼科]