谷胱甘肽转硫酶M1和T1基因型与新疆哈萨克族食管癌的关系  

Study on the relationship between glutathione S-transferase M1, T1 genotypes and Kazak esophageal cancer

作　　者：卢晓梅[1] 张月明[2] 林仁勇[1] 张亚楼[1] 阿孜古丽[1] 胡预兵[3] 温浩[1] 

机构地区：[1]新疆医科大学一附院中心实验室,新疆乌鲁木齐830054 [2]新疆医科大学公共卫生学院,新疆乌鲁木齐830054 [3]新疆维吾尔自治区人民医院病理科,新疆乌鲁木齐830000

出　　处：《疾病控制杂志》2003年第6期491-493,共3页Chinese Journal of Disease Control and Prevention

摘　　要：目的　为探讨与致癌物代谢有关的谷胱甘肽转硫酶 (GST) T1和 M1基因多型性与哈萨克族食管癌易感性的关系。方法　采用聚合酶链 (PCR)技术 ,分析新疆食管癌高发民族中 GSTM1和 GSTT1基因型分布的差异。结果　 GSTM1基因在食管癌、癌旁正常粘膜对照组中缺失率分别为 4 1.4 6 % (17/ 4 1)、34.15 % (14 / 4 1) ;GSTT1基因缺失率的分别为 4 8.78% (2 0 / 4 1)、5 1.2 2 % (2 1/4 1) ,差别均无显著性。同时 ,在食管癌组织的高分化组、中低分化组中 GSTT1和 GSTM1基因缺失率分别为 6 1.5 4 % (8/ 13)、4 2 .86 % (12 / 2 8)、15 .38% (2 / 13)、5 3.5 7% (14 / 2 8) ,其中 GSTM1基因缺失率在高、中低分化组中差别有统计学意义。结论　提示Objective To explore the association between genetic polymorphisms of glutathione S-transferase (GST) M1 and T1 and susceptibility to Kazak population esophageal cancer (EC). Methods A polymerase chain reaction method was used to detect absence of the GSTM1 and GSTT1 genes in genomic DNA in a high-risk ethnic, Xinjiang, China. Results The frequency of the GSTM1-null genotype in cancer cases (41.47%) was not significantly different from that in controls ( 34.15%). Similarly, no statistically significant differences were observed in the frequency of GSTT1-null genotype in cancer cases (48.78%) compared with control (51.22%). However, the frequency of GSTM1 null alleles genotypes in cases with well-differentiated cancer ( 15.38%) showed a significant decrease compared with that in poor-differentiated cancer ( 53.57%) (P<0.05). Conclusions GSTM1-null genotypes may act as risk factor in the development of poor-differentiated esophageal cancer in Kazak population.

关 键 词：谷胱甘肽转硫酶 M1 T1 基因型 新疆 哈萨克族 食管癌 GST 流行病学 肿瘤 

分 类 号：R735.1[医药卫生—肿瘤]