血清GPDA-F/ALT、GGT-II与AFP同步检测对肝细胞癌的诊断价值  

Simultaneous determination of serum GPDA-F/ALT,GGT-II and AFP for the diagnosis of primary hepatic carcinoma

作　　者：季颖林[1] 倪润洲[2] 黄介飞[2] 肖明兵[2] 李立人[2] 孟宪镛[2] 

机构地区：[1]南通医学院第二附属医院消化内科,南通226001 [2]南通医学院附属医院消化内科

出　　处：《南通医学院学报》2003年第4期390-390,393,共2页ACTA Academiae Medicinae Nantong

摘　　要：目的 :探讨甘氨酰脯氨酸二肽氨基肽酶 (GPDA-F/ALT)、r-谷氨酰转肽酶 (GGT- )和甲胎蛋白 (AFP)联合检测对肝癌的诊断价值。方法 :对 10 8例肝癌和 130例良性肝病患者进行了 GPDA-F/AL T、GGT-II和 AFP3项指标联合检测 ,分析这些指标对肝癌的互补诊断价值。结果 :肝癌患者 GPDA-F/ALT、GGT-II和 AFP3项指标均高于良性肝病 ;GPDA-F/ALT与GGT-II和 AFP之间无相关性 ;3项指标同步检测可明显提高肝癌的诊断敏感性。结论 :GPDA-F/ALT、GGT-II和 AFP3项指标对肝癌有互补诊断价值 ,联合检测能提高肝癌的诊断水平。Objective:To explore the value of GPDA-F/ALT, GGT-II and AFP in the diagnosis of primary hepatic carcinoma (PHC).Methods:GPDA-F/ALT, GGT-II and AFP were detected and their complementary diagnostic value to PHC was analyzed.Results:All of GPDA-F/ALT, GGT-II and AFP were significantly higher in PHC than in benign liver diseases. GPDA-F/ALT did not correlate with GGT-II and AFP. Simultaneous measurement of these three indices significantly improved diagnostic sensitivity to PHC.Conclusion:GPDA-F/ALT, GGT-II and AFP were complementary to PHC, and combined determination of these indices could improve the diagnosis of PHC.

关 键 词：血清 GPDA-F ALT GGT—Ⅱ AFP 检测 肝细胞癌 诊断 

分 类 号：R735.7[医药卫生—肿瘤]