脑出血急性期血清神经元特异性烯醇化酶的动态变化和意义  

Dynamic changes and significance of serum neuron specific enolase during acute period in the patients with intracerebral hemorrhage

作　　者：王光海[1] 田代实[1] 郭国际[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院神经内科,湖北武汉430030

出　　处：《中国急救医学》2003年第12期845-846,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　探讨神经元特异性烯醇化酶 (NSE)在脑出血急性期的动态变化及其临床意义。方法　用放射免疫法(RIA)检测 4 6例脑出血患者急性期NSE血清水平 ,观察NSE与出血量和神经功能缺损的相关性。结果　脑出血组血清NSE水平明显高于对照组 (P <0 0 5 ) ,发病 2 4h内即升高 ,在 (2 7± 0 9)d达到高峰 ,与出血量大小 (r =0 36 ,P <0 0 5 )和神经功能缺损程度 (r =0 34,P <0 0 5 )呈正相关。结论　NSE可以作为判断脑出血急性期病情严重程度和评估预后的指标之一。ObjectiveTo investigate the dynamic changes and clinical significance of serum neuron specific enolase(NSE)during acute period in the patients with intracerebral hemorrhage(ICH).MethodsThe serum levels of NSE in the patients with ICH were measured by radio-immunoassay method,the correlated analysis between NSE and the volume of hemorrhage and neurological function deficit was performed.ResultsThe serum levels of NSE was higher in the ICH group than in control group(P<0.05 or P<0.01),the serum levels of NSE increased in the first 24 hours after ICH,reached peak on (2.7±0.9) days after ICH,then began to decrease.The peak serum levels of NSE positively correlated with the volume of hemorrhage (r=0.36,P<0.05)and the neurological function deficit(r=0.34,P<0.05).ConclusionThe serum levels of NSE during acute period can serve as an indicator of seriousness and prognosis in patients with ICH.

关 键 词：脑出血 神经元特异性烯醇化酶 放射免疫法 急性期 

分 类 号：R743.34[医药卫生—神经病学与精神病学]