亚低温对脑梗死患者的脑保护作用研究  

Effect of Mild Hypothermia on NO, SOD and LPO in the Patient Suffered Cerebral Ischemia

作　　者：李玮[1] 吴晓华[1] 韩瑛[1] 陆红梅[1] 

机构地区：[1]上海市第七人民医院神经内科,200137

出　　处：《齐齐哈尔医学院学报》2003年第10期1091-1091,1093,共2页Journal of Qiqihar Medical University

摘　　要：目的　观察亚低温对脑梗死患者血清NO、SOD及LPO含量的影响。方法　随机将脑梗死患者分为亚低温组和对照组各 2 0例 ,亚低温组在药物治疗的基础上加用亚低温治疗 ,对照组为单纯的药物治疗。二组均在治疗前及治疗后 2 1d进行神经功能缺损评分 ,并在第 1d、第 3d、第 7d测定血清NO、SOD及LPO含量变化。结果　治疗 2 1d后亚低温组神经功能明显低于对照组 (P<0 .0 1)。血清SOD明显升高 ,NO和LPO下降 (P <0 .0 1)。结论　亚低温治疗具有升高血清SOD和降低NO和LPO水平的作用 ,从而表明血清NO、SOD及LPO含量变化是亚低温发挥脑保护作用机制的重要途径之一。Objective The study examined the effect of mild hypothermia on the levels of serum nitric oxide, superoxide dismutase and lipid peroxide in the patient if cerebral infarction with a large area. Methods The forty patients were randomly assigned to either mild hypothermia or control groups. Mild hypothermia group treated with mild hypothermia and drugs, control group only treated with drugs. Two groups were measured the levels of NO, SOD and LPO at 1, 3, and 5 day after cerebral ischemia. Results Neurogical function on mild hypothermia group was markedly decreased compared with control group at 21day(P<0.01). The levels of SOD was markedly increased and the levels of NO and LPO were markedly decreased (P<0.01). Conclusions Mild hypothermia can increased the level of SOD and reduced the levels of NO and LPO, which may be one of the most important ways for the neuroprotective effects of mild hypothermia.

关 键 词：亚低温 脑梗死 脑保护作用 药物治疗 神经功能缺损 血清 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R454.5[医药卫生—临床医学]