胃动脉插管化疗栓塞联合腹腔化疗治疗进展期胃癌  

A therapeutic study of gastric arterial chemotherapeutic infusion and embolization combined with abdominal chemotherapy to advanced gastric cancer

作　　者：李桂芳[1] 孙海[1] 杨兴华[1] 刘万菊[1] 翟群[1] 周有喜[1] 李子贺[1] 谢松柏[2] 张国民[2] 

机构地区：[1]解放军第454医院肿瘤科,南京210002 [2]解放军第454医院放射科

出　　处：《临床肿瘤学杂志》1999年第1期24-27,共4页Chinese Clinical Oncology

摘　　要：目的:为探讨对晚期进展期胃癌,进行胃动脉化疗栓塞并腹腔化疗双途径给药的可行性及临床疗效.方法:无法手术切除的进展期胃癌98例,随机分为三组,A组行胃动脉化疗栓塞并腹腔化疗;B组行腹腔化疗;c组行静脉化疗.结果:胃动脉化疗栓塞是可行的.A、B、C三组有效率分别为71.88%、38.7%和14.3%.A组与B、C组比较有明显差异(P<0.01).A组有5例完全缓解,且生存期延长.不良反应以胃肠道毒性和骨髓抑制为主.A组术后胃粘膜有损伤,四周后可恢复正常.结论:胃动脉化疗栓塞并腹腔化疗双途径给药是治疗晚期进展期胃癌的有效方法.Objective:To obseve the probability and clinical curative effect of gastric arterial chemotherapeutic infusion and em-bolization(GAI + GAE) combined with abdominal chemotherapy to advanced gastric cancer. Methods:98 patients with advanced gas-tric cancer were randomized into three groups, group a was treated with GAI + GAE combined with abdominal chemotherapy, group B with abdominal chemotherapy and group C with intravenous chemotherapy. Results: The response rtae for group A, B, C was 71. 88%, 38.71 % and 14.29% . THe median survival duration for group A, B, C was 16,10 and 8 months. The response rate and medi-an survival duration of group A was better than group B(P<0.01) or group C(P<0.01),5 patients in group A acquired complete remission. The main side effects were gastrointestinal toxicity and arrest of bone marrow.Conclusion:GAI + GAE combined with ab-dominal chemotherapy was a effective cure to advanced gastric cancer.

关 键 词：腹腔 治疗 胃癌 临床资料 副反应 胃动脉插管化疗栓塞 

分 类 号：R735.2[医药卫生—肿瘤]