骨囊肿、骨巨细胞瘤和骨肉瘤的计算机图象定量研究  

Cytomorphometric analysis of human bone cyst, giant cell tumor of bone and osteosarcoma

作　　者：许建波[1] 方睿才 李琳 欧阳明[3] 

机构地区：[1]云南省肿瘤医院骨科,昆明650106 [2]云南省人民医院,昆明650032 [3]云南大学实验中心,昆明650032

出　　处：《临床肿瘤学杂志》1999年第1期10-12,共3页Chinese Clinical Oncology

基　　金：本课题为云南省卫生厅科研基金资助项目

摘　　要：目的:研究和解决骨巨细胞瘤的传统组织学分级与生物学行为不甚相符的问题.方法:利用自动图象分析仪对13例骨囊肿,51例骨巨细胞瘤(GCT)和15例骨肉瘤,共计79例标本进行了8项参数的形态定量研究.结果:在8项参数中,核X_6(核圆度)、X_7(核椭率)在不同肿瘤或分级的两两比较中全部无显著性差异;其余6项参数GCTⅠ、Ⅱ级均无显著性差异,而 GCTⅠ级与骨囊肿、Ⅲ级骨肉瘤各组间均有显著性差异,GCTⅡ级与骨囊肿、Ⅲ级骨肉瘤各组织间也有显著性差异.结论:经计算机图象定量研究,将8项参数经多元逐步判别分析,结果优选出有较多诊断价值的3项参数见、X_1、X_5、X_8,并依次建立判别函数方程(回归方程).Objective: :This study was designed to solve the problem that the tradititional tissure classification on giant cell tumor of bone(GCT) did not accord with its biological behavior. Method: The automatic image analyser was Applied morphometric study in 79 sepeciment. There were 13 cases of bone cyst, 51 cases of giant cell of bone, 15 cases of osteosarcoma. . Eight parmeters were morphomtrically mesured and calculated. Results:It was showed that X_(6)(nuclear circular degree), X7(nuclear elipicity) of 8 pa-rameters were no significant each and all tumor or system of grade. The author thought other 6 patameters were useful, there was no signifficant difference bettween gread I and II of GCT. There was significant difference among grade between I ? II of GCT and bone cyst, grade III GCT and osteosarcome. Conclusion: The author also established an regression equation on quantitative morpho-metric analysis, which was reference value for pathology clinical diagnesis.

关 键 词：骨囊肿 骨巨细胞瘤 骨肉瘤 计算机 GCT 临床资料 

分 类 号：R738.1[医药卫生—肿瘤]