Ⅰ期非小细胞肺癌术后复发转移影响因素分析  

Analysis of Influencing Factors of Postoperative Recurrence and Metastasis of Stage Ⅰ Non-small Cell Lung Carcinoma

作　　者：纪永棋 荣振华 魏煜程 

机构地区：[1]青岛大学 [2]曹县人民医院

出　　处：《世界最新医学信息文摘》2017年第87期18-20,共3页World Latest Medicine Information Electronic Version

摘　　要：目的分析I期非小细胞肺癌患者的临床病理特征,探讨术后复发转移的影响因素。方法回顾性分析自2006年1月至2013年12月在本院手术治疗的93例I期非小细胞肺癌患者包括术前PNI在内的各项临床病理资料。采用SPSS19.0统计软件进行数据分析,通过绘制受试者工作特征曲线选取PNI截断值,绘制Kaplan-Meier生存曲线。单因素分析采用χ~2检验,多因素分析采用Cox回归模型。结果全组93患者中共有29例复发,复发率为31.2%。单因素分析显示性别、PNI、病理类型、肿瘤大小为术后复发转移的影响因素,多因素分析显示PNI和肿瘤大小是术后复发转移的影响因素。低PNI患者的复发转移概率约为高PNI患者的2.65倍。T2a的复发转移概率约为T1的2.91倍。结论术前预后营养指数和肿瘤大小是I期非小细胞肺癌术后复发转移的影响因素。PNI指数越低、肿瘤体积越大的患者术后越易复发。Objective To analyze the clinicopathological features of stage I non-small cell lung carcinoma, find the risk factors of recurrence and metastasis. Methods The clinical data of 93 patients with stage I non-small cell lung carcinoma, including preoperative PNI, were retrospectively analyzed from January 2006 to December 2013 in our hospital. SPSS19.0 statistical software was used for data analysis, by drawing the receiver operating characteristic curve, the PNI truncation value was selected, draw the Kaplan-Meier survival curve. The χ~2 test was used in the single factor analysis, and the Cox regression model was used in the multiple factor analysis.Results There were 29 recurrences in 93 patients, and the recurrence rate was 31.2%.Univariate analysis showed that gender, PNI, histopathology and tumor size were the related factors of postoperative recurrence after operation, multivariate analysis showed that PNI and tumor size were the influencing factors of postoperative recurrence.The probability of recurrence and metastasis in patients with low PNI was about 2.65 times higher than in patients with high PNI. The probability of recurrence and metastasis of T2 a was about 2.91 times of that of T1. Conclusion Preoperative prognostic nutritional index and tumor size are the related factors for postoperative recurrence and metastasis of stage I non-small cell lung carcinoma.The lower PNI the greater the tumor size, the more likely the patient will relapse.

关 键 词：I期非小细胞肺癌 术后复发转移 影响因素 PNI 

分 类 号：R734.2[医药卫生—肿瘤]