多潘立酮对不同证型功能性消化不良患者胃动力的影响及临床疗效研究  

Effects of Domperidone on Clininal Effectiveness and Gastric Motility of FD Patient in Different TCM Syndrome Types

作　　者：张伟[1] 张雅楠 ZHANG Wei;ZHAGN Ya-nan(Department of Spleen and Stomach,Shandong Tai’an Hospital of Traditional Chinese Medicine,Tai’an Shandong;Department of Gastroenterology,Shandong Tai’an Central Hospital,Tai’an Shandong)

机构地区：[1]山东泰安市中医医院脾胃科 [2]山东泰安市中心医院消化二科

出　　处：《世界最新医学信息文摘》2018年第72期43-45,共3页World Latest Medicine Information Electronic Version

摘　　要：目的研究多潘立酮对不同证型功能性消化不良患者胃动力的的的影响及临床疗效。方法确诊的FD运动障碍型患者60例:肝郁气滞型及脾虚气滞型各30例,另选10例健康查体者做正常对照组。两证型患者均给予多潘立酮片10mg日3次,饭前30分钟口服,疗程15天。观察治疗前后两证型患者的临床疗效及胃电参数变化。结果治疗后脾虚气滞组的症状积分小于肝郁气滞组,且总效率86.7%,高于肝郁气滞组50%,差异显著(c2=2.58,P<0.05)。治疗后两组的胃电节律较治疗前明显改善。治疗前两组餐前后的胃电功率均低于正常组,但肝郁气滞组与正常组相比,无差异性P>0.05)。治疗后餐前餐后的胃电功率增加,脾虚气滞组的餐前餐后胃电功率增加,差异显著P<0.05)。肝郁气滞组餐前后的增加无差异性。结论多潘立酮对不同证型的FD患者临床疗效及胃电图影响不同,对脾虚气滞组优于肝郁气滞组。Objective To investigate the curative effects and gastric dynamic index change of Domperidone on different TCM syndrome types in patients with functional dyspepia(FD). Methods 60 cases of FD with gastric dyskinesia patients were divided into 2 groups:spleen-deficiency-qi-stagnation group(30 cases)and liver-qi-stagnation group(30 cases). Another 10 healthy volunteers were selected as nomal control.The FD patients were treated with Domperidone Tablets 5 mg,3 times a day,oral 30 minute before meal,for 15 days.To observe the total effective rate of symptoms and single symptoms,and the changes of elecrogastrogram,compared with those of the normal group. Result After treatment,the total score of FD group and the effective rate of single symptom were all improved(P<0.05). The clinical effective rate of spleen-deficiency-qi-stagnation group was obviously better than that of liver-qistagnation(86.7%v50%)(P<0.05). Compared with the normal group the liver-qi-stagnation group and spleen-deficiency-qi-stagnation group had obvious abnormity in gastric electrogram rhythm before treatment(P<0.05). While their gastric electrogram rhythm had been improved after treatment.Preprandial and postprandial normal slow waves of elecrogastrogram and electric power were improved(P<0.05), but the spleen-deficiency-qi-stagnation group was better than the liver-qi-stagnation group in total effective rate and partly gastric dynamics index(P<0.05). Conclusion The clinic effectiveness of Domperidone Tablets for FD patients with TCM diagnosis of spleen-deficiency-qi-stagnation and gastric dyskinesia is significant.

关 键 词：功能性消化不良 脾虚气滞证 肝气郁滞证 胃动力障碍 多潘立酮 

分 类 号：R57[医药卫生—消化系统]