羟基磷灰石和骨生长因子复合修复颌骨缺损的实验研究  

The experimental study of hydroxyapatites combined with bone growth factor to repair mandibular defects

作　　者：高云静[1] 刘新[2] 张海燕[2] 

机构地区：[1]北华大学附属医院口腔科 [2]吉林大学中日联谊医院

出　　处：《中国实验诊断学》2003年第6期493-494,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的　观察羟基磷灰石 (HA)和骨形成蛋白 (BMP)及碱性成纤维细胞生长因子 (bFGF)复合物修复颌骨缺损的骨形成反应。探讨碱性成纤维细胞生长因子诱导骨形成的影响。方法　Wister大鼠 10 0只随机分为 5组 ,每组 2 0只 ,设立HA bFGF为实验组 ,HA BMP ,BMP bFGF ,HA ,及空白组 4组做为对照组分别于术后 7天、3个月 5个时间来取材 ,进行组织学、透射电镜观察、X线检查 ,观察骨组织愈合情况。结果　HA BMP bFGF组在诱导新骨形成方面及成骨量均高于对照组。结论　HA BMP bFGF复合物可以做为一种新的骨修复材料在颌骨缺损中进行应用。碱性成纤维细胞生长因子在骨诱导中能发挥协同与促进作用 ,使新骨形增多。Objective To study the effects of hydroxyapatite combined with bone morphogenetic protein and basic fibroblast growth factor in repair of mandibular defects.Methods 100 Wistar rats were classified into five groups: HA/BMP/bFGF、HA/BMP、BMP/bFGF、 HA and no materials groups. At 7、90、150、days after operation, the effectivenesses of defect repair were observed by histological analysis.Results The ablity of bone inductivity was better in HA/BMP/bFGF groups than the other groups.Conclusion The composites of HA/BMP/bFGF is a new kind of materials in repair of bone defects and bone fibroblast growth factor can promote bone fomation .

关 键 词：羟基磷灰石 骨生长因子 修复 颌骨缺损 实验研究 

分 类 号：R782.2[医药卫生—口腔医学]