复合牛骨形成蛋白多孔中空种植体成骨效应的研究  

Behavior of Bone Formation around the Porous-hollow Cylindrical Titanium Implant Composed of Bone Morphogentic Protein

作　　者：廖湘凌[1] 陈绍维[2] 李声伟[3] 田卫东[3] 张杰[4] 

机构地区：[1]北京市通州区潞河医院口腔科,101100 [2]中山大学附属二院口腔颌面外科 [3]四川大学华西口腔医院口腔颌面外科 [4]四川大学华西临床医学院电镜室

出　　处：《华西口腔医学杂志》2003年第6期428-431,共4页West China Journal of Stomatology

基　　金：四川省科委重点科研项目基金资助项目 (编号G960 0 2 )

摘　　要：目的　利用激光扫描共聚焦显微镜 (LSCM)观察牛骨形成蛋白复合种植体成骨效应。方法　将天然提取的牛骨形成蛋白 (bBMP)与多孔中空钛种植体相复合形成人工复合种植体 ,植入狗下颌骨 ,并设同等规格的实心柱状钛种植体及不复合bBMP的多孔中空柱状钛种植体植入狗下颌骨为对照组。应用三色荧光标记LSCM观察复合种植体周围骨整合情况。结果　实验组复合种植体在各时期成骨能力和成骨量均明显优于对照组。结论　复合种植体可诱导早期、大量、较持久的成骨 ;LSCM对种植体周围成骨行为进行观察是一种准确、有效的手段。Objective The purpose of this study was to observe the behavior of bone formation around the titanium-hollow porous cylinder implant composed of bovine bone morphogentic protein(bBMP).Methods Porous-hollow cylinder titanium implant composed of bBMP was implanted into mandibule of dogs. Multiple fluorescent was labeled at different times and then LSCM was used to observe the newly formed bone around the complex implant.Results The newly formed bone around the complex implant in experimental group was more obvious than that in other groups. Conclusion Earlier, longer and more new-bone formation can be induced by porous-hollow cylinder titanium implant composed of bBMP, and LSCM is an effective method to observe new bone formation around implant.

关 键 词：复合牛骨形成蛋白多孔中空种植体 成骨效应 激光扫描共聚焦显微镜 骨形成蛋白 骨整合 

分 类 号：R783.1[医药卫生—口腔医学]