口腔白斑及鳞癌中Rb、P^(53)蛋白的表达  

The expression of Rb and P^(53) in oral leukoplakia and oral squamous cell carcinoma

作　　者：卢怡[1] 高文信[2] 牛忠英[1] 欧阳喈[2] 施生根[1] 姜萍[1] 

机构地区：[1]北京解放军306医院口腔科,100101 [2]长春吉林大学口腔医学院

出　　处：《实用口腔医学杂志》2003年第6期569-572,共4页Journal of Practical Stomatology

摘　　要：目的 :探讨抑癌基因p5 3 、Rb蛋白产物在口腔白斑及鳞癌中的表达。方法 :用免疫组化法检测 2 0例口腔白斑 (OLK)、3 3例鳞癌 (OSCC)组织中P5 3 及Rb蛋白的表达。结果 :Rb蛋白在OLK、OSCC中的表达较正常口腔黏膜组增强 ,但无显著性差异 ;突变型P5 3 蛋白的表达在OLK即已出现 ,且随着细胞异常增生程度的增高而增强 ,在OSCC中其阳性表达率高达 80 %。结论 :p5 3 基因突变、P5 3 蛋白过度表达与OSCC的发生发展密切相关 ;OSCC的发生可能涉及Rb、p5 3Objective: To observe the expression of proteins Rb and P 53 in leukoplakia (LK) and squamous cell carcinoma (SCC) of oral muco sa. Methods: The expression of proteins Rb and P 53 was determined by immunohistochemical S-P method. Paraffin sections of 33 s amples of SCC and 20 of LK were immunohistochemically stained and analyzed. Results: (1)The expression of Rb in OLK, OSCC was not si gnificantly different from that in normal oral mucosa ;(2)the overexpression of mutant P 53 were found in OLK and its expression was increasing with dysp hasia degree (P<0.05). The positive rate of mutant P 53 in OSCC was up t o 80% (25/33). Conclusions: p 53 mutation may be an early event in the pathogenesis of OSCC;

关 键 词：口腔白斑 口腔鳞癌 RB蛋白 P^53蛋白 基因突变 基因表达 

分 类 号：R739.85[医药卫生—肿瘤]