复发性口疮与幽门螺杆菌感染免疫相关性研究  

The relationship between recurrent aphthae and immunologic reaction on Helicob acter pylori infection

作　　者：王淑丽[1] 张纯[1] 王军[1] 刘向辉[1] 张玲[1] 周红文[1] 黄辉[1] 靳静[1] 章健[1] 

机构地区：[1]江苏南京市解放军第81医院口腔科,210002

出　　处：《实用口腔医学杂志》2003年第6期640-642,共3页Journal of Practical Stomatology

摘　　要：目的 :探讨复发性口疮的发生与幽门螺杆菌 (H .pylori)感染相关性免疫反应的关系 ,旨在了解H .pylori感染在复发性口疮发生机制中的作用及意义。 方法 :采用快速尿素酶实验及ELISA等方法检测复发性口疮患者和正常对照人群牙菌斑中H .pylori的存在情况及其血中的抗H .pylori抗体的水平。结果 :复发性口疮患者口腔牙菌斑中H .pylori的检出率 (53 .3 % )明显高于正常对照人群 (3 2 .3 % )(P <0 .0 1) ,口腔牙菌斑中H .pylori的检出率与复发性口疮的严重程度之间无明显关系 (P >0 .0 5) ;血中抗H .pylori抗体的检出率与复发性口疮及其严重程度之间无明显关系 (P >0 .0 5)。而血中抗H .pylori抗体的浓度水平与复发性口疮及其严重程度明显相关 (P <0 .0 1)。 结论 :口腔中的H .pylori感染与复发性口疮的发生相关 ,而血液中由H .Objetive:To investigate the relationship between recurre nt aphthae and immunologic reaction on Helicobacter pylori (H. pylori) i nfection. Methods: The dental plaque was collected and the blood serum were extracted from 107 patients with recurrent aphthae and 99 he althy individuals. H. pylori infection was detected by urease test, and the antibody to H. pylori was detected by ELISA assay. Results: In the dental plaque the detectable rate of H. pylori was 53.3% in t he patients and 32.3% in the controls (P<0.01). In dental plaque there was no statistical difference between light (51.7%) and heavy ( 61.1 %) recurre nt aphthae in the detectable rate of H. pylori and anti-H. pylori antib ody (P>0.05). The quantitative analysis showed that the level of anti-H . pylori antibody (μg/ml) in the controls,the patients with light recurrent a phthae and those with severe was 17.69±4.41,29.30±8.24 and 41.75± 9.73 res pectively (P<0.01). Conclusion: The autoimmune reacti on induced by H. pylori infection may be a pathogenic mechanism in the occ urrence of recurrent aphthae.

关 键 词：复发性口疮 幽门螺杆菌感染 免疫学 相关性 发病机制 

分 类 号：R781.51[医药卫生—口腔医学]