血清血管内皮细胞生长因子与肝细胞癌临床关系的研究  

Study on the Relationship of Serum Vascular Endothelial Growth Factor (VEGF) andPrognosis in Human Hepatocellular Carcinoma After TACE

作　　者：熊正平[1] 杨树仁[1] 肖恩华[1] 朱美香[1] 

机构地区：[1]中南大学湘雅二院放射科

出　　处：《临床放射学杂志》2003年第B09期85-87,84,共4页Journal of Clinical Radiology

基　　金：国家自然科学基金资助项目 (基金号 :3 0 0 70 2 3 5 )

摘　　要：目的　检测肝细胞癌 (HCC)经导管化疗栓塞 (TACE)前血清血管内皮细胞生长因子 (VEGF)水平 ,并研究其与HCC侵袭 ,特别是复发转移的关系。资料与方法　前瞻性对 30例HCC患者分别于术前取外周静脉血采用酶联免疫夹心法 (ELISA)定量测量血清VEGF水平 ,于TACE术后 3个月评估患者肝癌复发转移发生情况 ,同时以 2 0例健康男性作为对照组予以对照。结果　 (1)对照组 2 0例血清VEGF水平为 2 2 .82± 10 .95ng/L ;(2 ) 30例HCC患者术前血清VEGF水平为 15 4 .4 7± 90 .17ng/L ,与对照组比较有统计学意义 (P =0 .0 0 0 1) ;(3)转移肝癌组患者术前的血清VEGF为 2 11.0 6± 112 .11ng/L ,显著高于非转移肝癌组患者 (135 .79± 4 9.82ng/L ,P <0 .0 5 )。追踪半年期间 ,血清VEGF高水平组 (>10 0ng/L)患者中 74 %再发 ;而血清VEGF低水平组 (<10 0ng/L)的患者中无 1例再发。结论　血清VEGF高水平是对应的肿瘤组织高表达的结果 ,与TACE术后HCC复发转移发生有关 。Objective To prospectively evaluate changes in serum Vascular endothelial growth factors (VEGF) level in hepatocellular carcinoma (HCC) patients before transcatheter arterial chemoembolization (TACE), and the relationship between serum VEGF levels after TACE and HCC progression, especially associated with metastasis. Materials and Methods Serum VEGF levels were measured before TACE in 30 patients with HCC and 20 healthy volunteers in this study. The patients were evaluated for the occurrence of recurrence and metastasis from HCC after 3 months. Serum VEGF levels were measured by quantitative sandwich enzyme linked immunosorbent assay (ELISA R&D system). Results There was significant difference of the serum VEGF levels between 20 healthy adults (22.82±10.95ng/L) and 30 patients with HCC (154.47±90.17 ng/L). The serum VEGF level of hepatic metastases(211.06±112.11ng/L) was significantly higher than that of non metastatic malignant hepatic tumors(135.79±49.82ng/L)(P<0.05). During half a year of follow up, 20 patients in group of high serum VEGF (74%) recurred, but patients in group of low serum VEGF did not recurred. Conclusion Serum VEGF level is closely related to the recurrence and metastasis of HCC after TACE. Serum VEGF is a tumor maker for prognosis in human hepatocellar carcinoma after TACE.

关 键 词：血清 血管内皮细胞生长因子 肝细胞癌 经导管化疗栓塞 肿瘤复发 肿瘤转移 

分 类 号：R735.7[医药卫生—肿瘤]