水通道蛋白1与角膜内皮  

Aquaporin 1 and corneal endothelium

作　　者：彭洁[1] 张虹[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院眼科,430030湖北武汉

出　　处：《眼科新进展》2003年第6期449-452,共4页Recent Advances in Ophthalmology

摘　　要：水通道蛋白 (aquaporins,AQPs)是存在于动植物及微生物细胞膜上的一组与水通透有关的转运蛋白 ,参与许多生理过程 ,维持机体的正常状态。第一个水通道蛋白AQP1的cDNA序列是在 1991年完成鉴定的 ,它存在于包括眼在内的多种组织和细胞中。角膜内皮细胞上也发现有AQP1的表达 ,随着对AQP1结构及功能认识的逐步深入 。Aquaporins(AQPs) are a group of transport protein related to water permeability. They are presently in cell membranes of animals,plants and microorganisms,taking part in many physiological processes and maintaining normal bodily behaviors. The cDNA sequence of the first familial member AQP1 was identified in 1991. It exists in many various tissues and cells including the eye. Corneal endothelium expresses AQP1 too. With understanding the structure and function AQP1 step by step, its transportion of water through cell membranes and other possible functions were found to be important to clarify keratopathy and to maintain corneal transparency.

关 键 词：水通道蛋白1 角膜内皮 

分 类 号：Q51[生物学—生物化学] R771[医药卫生—眼科]