肝癌MAGE-n抗原HLA-A2限制性细胞毒性T细胞表位的预测  

Prediction of HLA-A2-restricted CTL epitope derived from hepatocellular carcinoma antigen MAGE-n

作　　者：黄小兰[1] 董海龙[2] 隋延仿[2] 

机构地区：[1]西安市中心医院医务科,陕西西安710003 [2]第四军医大学病理学教研室,陕西西安710032

出　　处：《现代肿瘤医学》2003年第5期325-327,共3页Journal of Modern Oncology

基　　金：国家自然科学基金重点项目 (项目编号 :39830 4 2 0 )

摘　　要：目的　预测肝癌MAGE -n抗原HLA -A2限制性细胞毒性T淋巴细胞 (CTL)表位。方法　应用SYFPEITHI超基序多项式法远程预测系统和量化基序多项式法结合的预测方法 ,筛选MAGE -n抗原HLA -A2限制性CTL表位。结果　筛选到MAGE -n抗原 5个HLA -A2限制性CTL表位 (九肽 )。结论　SYFPEIObjective To predict the HLA-A2-restricted Cytotoxic T Iymphocyte(CTL) epitopes of hepatocellular carcinoma novel antigen MAGE-n.Methods The HLA-A-A *0202-restricted CTL epitopes of hepatocellular carcinoma antigen MAGE-n were prdicted by SYFPEITHI prediction methods combined with the polynomial methods.Results Five HLA-A2-restricted CTL epitope candidatds derived from the tumor antigen MAGE-n were selected by prediction methods SYFPEITHI combined with the polynomial method. Conclusion The combination of SYFPEITHI prediction method and polynomial method can improve the prediction efficiency and accuracy.

关 键 词：肝癌 免疫治疗 MAGE-N CTL表位 SYFPEITHI超基序法 量化基序多项式法 

分 类 号：R735.7[医药卫生—肿瘤] R730.51[医药卫生—临床医学]