The susceptibility gene for familial nasopharyngeal carcinoma is mapped on chromosome 4p11-p14 by haplotype analyses  

作　　者：CHEN Hankui, FENG Bingjian, LIANG Hui, ZHANG Ruhua & ZENG Yixin Cancer Center, Sun Yet-sun University, Guangzhou 510060, China Correspondence should be addressed to Zeng Yixin (e-mail: yxzeng@ gzsums.edu.cn) 

出　　处：《Chinese Science Bulletin》2003年第21期2327-2330,共4页

基　　金：supported by the China Medical Board(CMB 98-678);the National“973”Key Basic Research Projects(Grant No.G19980510);the Foundation of Guangdong Science and Technology Committee(9800 1-4,980950).

摘　　要：In our previous study, one candidate suscepti-bility locus for familial nasopharyngeal carcinoma (NPC) has been defined to a 14.21-cM region on 4p15.1-q12, whereas the distal minimum boundary of this region remained to be further determined in respect that the two markers D4S2996 and D4S428 were uninformative. In the present study, we carried out a haplotype analysis to identify the exact bound-ary by using the combination of a set of microsatellite mark-ers and single nucleotide polymorphism (SNP) markers in two major NPC families. We defined the exact distal bound-ary between D4S1577 and D4S3347, and consequently shortened the susceptibility locus to an 8.29-cM segment on 4p11-p14.In our previous study, one candidate suscepti-bility locus for familial nasopharyngeal carcinoma (NPC) has been defined to a 14.21-cM region on 4p15.1-q12, whereas the distal minimum boundary of this region remained to be further determined in respect that the two markers D4S2996 and D4S428 were uninformative. In the present study, we carried out a haplotype analysis to identify the exact bound-ary by using the combination of a set of microsatellite mark-ers and single nucleotide polymorphism (SNP) markers in two major NPC families. We defined the exact distal bound-ary between D4S1577 and D4S3347, and consequently shortened the susceptibility locus to an 8.29-cM segment on 4p11-p14.

关 键 词：染色体 易受性遗传基因 鼻咽癌 单模标本分析 

分 类 号：R739.63[医药卫生—肿瘤]