内、外侧痛觉系统——伤害性信息处理的并行通路  

The medial and lateral pain system—parallel processing of nociceptive information

作　　者：王锦琰[1] 罗非[1] 韩济生[1] 

机构地区：[1]北京大学神经科学研究所,北京大学神经生物学系北京100083

出　　处：《中国神经科学杂志》2003年第6期416-419,共4页

基　　金：国家自然科学基金资助项目 (3 0 170 3 0 7)

摘　　要：现代研究认为 ,完整的痛觉信号应该包括两种成分 ,即反映伤害性刺激参数 (性质、定位、强度 )的感觉辨别成分和反映情绪效应以及产生逃避行为的情感动机成分。相应地 ,在脑内存在两条平行上传的通路 ,分别传递痛的感觉和情绪信息。其中由脊髓背角深层广动力神经元发出 ,经过丘脑外侧核群投射到躯体感觉皮层的通路 ,可能传导伤害性刺激的感觉信息 ,称为外侧痛觉系统 ;由脊髓背角浅层痛觉特异性神经元发出 ,经由丘脑中线核群及板内核群投射到前扣带回和岛叶的通路 ,可能传递伤害性刺激的情绪成分 ,称为内侧痛觉系统。The experience of pain is described along two main dimensions: (1) the sensory-discriminative dimension that comprising stimulus location,intensity,and quality and (2) the affective-motivational dimension,related to the pain unpleasantness as well as the avoidance behaviors. It is possible that these two dimensions are mediated by separate neural systems. A projection derived from the deep dorsal horn through the lateral thalamus to somatosensory cortex is thought to transmit information regarding pain sensation,which forms the lateral pain system. Another system originating from the superficial spinal dorsal horn and projecting through the medial thalamic nuclei to the anterior cingulate cortex (ACC) and insular cortex (IC) has been proposed to process information related to pain affect,which is termed the medial pain system.

关 键 词：内侧痛觉系统 外侧痛觉系统 伤害性信息处理 并行通路 躯体感觉皮层 

分 类 号：R741[医药卫生—神经病学与精神病学]