高频正弦波振动对失重性肌萎缩的对抗作用  

Counteracting effects of high frequency vibration on simulated weightlessness-induced atrophy of soleus muscles in rats

作　　者：任俊蝉[1] 樊小力[1] 宋新爱[1] 朱永进[1] 

机构地区：[1]西安交通大学医学院生理学教研室,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2003年第6期527-530,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金项目 (No .30 0 70 830 )

摘　　要：目的　探讨高频正弦波振动对模拟失重条件下大鼠比目鱼肌萎缩的对抗作用。方法　将SD大鼠按体重匹配的原则随机分为同步对照 (CON)、模拟失重 (SUS)、模拟失重 +高频振动 (SUS +HFV) 3组。 7d后 ,取大鼠比目鱼肌(SOL)称其湿重 ,计算其湿重体重比。采用组织酶化学染色及计算机图象分析技术对大鼠比目鱼肌I、II型肌纤维比例、横截面积 (CSA)进行定量分析。结果　与CON组对比 ,SUS组比目鱼肌湿重体重比、横截面积明显减小 ,同时I型纤维比例减少而II型纤维比例增加 (P <0 .0 5 )。SUS +HFV组比目鱼肌湿重体重比、横截面积及I、II型纤维的构成比与CON组对比均无明显差异 (P >0 .0 5 )。Objective To study counteracting effects of high frequency vibration on simulated weightlessness-induced atrophy of soleus muscles in rats. Methods Female Sprague-Dawley (SD) rats were assigned randomly to one of the three groups: simultaneous control (CON), simulated weightlessness (SUS), and SUS plus high frequency vibration (SUS+HFV). Soleus muscles were examined 7 days later. Sections were treated with adenosinetriphosphatase (ATPase) stain. The cross-sectional areas (CSA) of fibers, the relative proportion of types I and II were measured using Leica image analysis system. Results Compared with those of CON, the wet weight /body of soleus and the cross-sectional areas (CSA) of type I/II fibers in SUS were significantly reduced. The relative proportion of type I fibers in SUS was reduced and type II fibers increased. In SUS+HFV group, the wet weight/body of soleus and the cross-sectional areas (CSA) of type I/II fibers recovered completely. The relative proportion of type I/II fibers recovered completely. Conclusion The present study demonstrates that HFV is effective in counteracting the muscle atrophy induced by simulated weightlessness.

关 键 词：高频正弦波振动 失重性肌萎缩 大鼠 HFV 肌纤维 肌张力 

分 类 号：R746.4[医药卫生—神经病学与精神病学]