强电脉冲治疗肿瘤提高抗癌药物疗效的研究  

Study of High-intensity Electric Pulse Inhibited Sarcoma for Improving Antitumor Drug Effect

作　　者：李虹[1] 王子淑[1] 岳碧松[1] 邹方东[1] 杨孔[1] 孙敬儒[1] 王保义[2] 张弘[2] 陈海川[2] 杨果[2] 

机构地区：[1]四川大学生命科学学院,成都610064 [2]四川大学无线电系,成都610064

出　　处：《生物医学工程学杂志》2003年第4期612-614,共3页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目 (60 0 710 2 4);四川省科技厅资助项目 (0 2 SY0 2 9-12 7)

摘　　要：报道了用强电脉冲结合抗癌药物环磷酰胺作用于昆明小鼠 S- 180肉瘤。实验结果表明 ,电场 +药物组的治疗效果最佳 ,与对照组相比 ,呈显著差异。同时观察到电场的作用可以抑制肿瘤的微血管形成 ,这样就减少了对癌细胞的营养供应、降低其新陈代谢 ,从而抑制了肿瘤的生长。This article reports the experiment studies on treating the S 180 sarcomas of KM mice with high intensity electric pulse and antitumor drug (cyclophosphamide). The results showed that the experimental group of electric field combined with drug has the best effect on tumor, compared with the control group. In addition, electric field can inhibit the formation of vas capillares and decrease the supply of nutrition for tumor cell. In conclusion, electric field has inhibited the growth of tumor.

关 键 词：强电脉冲 治疗 肿瘤 抗癌药物 电穿孔 S-180肉瘤 

分 类 号：R73-36[医药卫生—肿瘤]