盐酸罂粟碱氯化钠注射液细菌内毒素检测法实验研究  

Assay for bacteririal endotoxin in papaverine hydrochloride and sodium chloride injection

作　　者：金卫红[1] 居红枫[1] 

机构地区：[1]江苏省药品检验所,江苏南京210008

出　　处：《药学实践杂志》2003年第6期341-343,共3页Journal of Pharmaceutical Practice

摘　　要：目的:建立盐酸罂粟碱氯化钠注射液的细菌内毒素检查方法。方法:用两个生产厂的鲎试剂对盐酸罂粟碱氯化钠注射液进行干扰试验研究。结果:盐酸罂粟碱氯化钠注射液对细菌内毒素检查无干扰作用。结论:可以用细菌内毒素检查法(凝胶法)代替家兔热原检查法控制其热原。OBJECTIVE: To establish the method of assay for the bacterial endotoxin in papaverine hydrochlo-ride and sodium chloride injection. METHODS: Inhibition and enhancement test was performed with limulus ame-bocyte lysate manufactured by two different companies. RESULTS:The injection will not interfere to the bacterial endotoxins test. CONCLUSIONS: The results suggest that bacterial endotoxins test (gel-clot method) can be used as an replaceable method for the rabbit pyrogen test for papaverine hydrochloride and sodium chloride injection.

关 键 词：盐酸罂粟碱氯化钠注射液 细菌内毒素检测法 实验 凝胶法 

分 类 号：R927.1[医药卫生—药学]