抽动障碍患儿A族溶血性链球菌抗体的测定  

Detection of group A streptococcal antibody in children with tic disorders

作　　者：金嵘[1] 徐惠琴[2] 黄文武 陈宏[4] 郑荣远[2] 邵蓓[2] 黄海波[2] 叶好好[5] 

机构地区：[1]温州医学院附属第一医院流行病学教研室感染管理科,325000 [2]温州医学院附属第一医院神经内科,325000 [3]温州市精神病院心身科 [4]温州医学院附属第一医院精神科,325000 [5]温州医学院附属第一医院神经免疫室,325000

出　　处：《中华精神科杂志》2003年第4期231-233,共3页Chinese Journal of Psychiatry

基　　金：浙江省温州市科学技术委员会基金资助项目(S2 0 0 0A16);浙江省医学重点学科(神经病学)基金资助(970 15 )

摘　　要：目的　探讨A族溶血性链球菌感染在抽动障碍发病中的作用。方法　采用抗DNA酶B微量法 ,测定 4 6例抽动障碍患者和 4 6名健康对照的抗DNA酶B抗体。结果　抽动障碍患者抗DNA酶B的几何平均滴度 ( 0 19U/L)高于健康对照 ( 0 12U/L ;t=2 17,P <0 0 5 ) ;抗DNA酶B的阳性率 ( 5 2 % ,2 4 / 4 6 )也高于健康对照组 ( 30 % ,14 / 4 6 ) ,差异有显著性 ( χ2 =4 4 8,OR =2 4 9,P <0 0 5 )。抽动障碍患者抗DNA酶B滴度与耶鲁抽动症整体严重度量表评分间呈正相关 (r=0 35 ,P <0 0 5 )。Objective To explore the role of Group A streptococcal infection in children with tic disorders Methods Anti DNase B antibodies in 46 patients with tic disorders and 46 normal children were detected by Anti DNase B antibody microtitration test Results In children with tics, geometric mean of Anti DNase B antibody (0 19 U/L) was significantly higher than that in control subjects (0 12 U/L; t= 2 17, P< 0 05) The positive rate of Anti DNase B antibody (24/46) was significantly higher than normal children (14/46; χ 2=4 48, OR= 2 49, P< 0 05) In children with tics, a positive correlation between Anti DNase B antibody titers and severity of tic disorder was found ( r= 0 35, P< 0 05) Conclusion Group A streptococcal infection might be correlated to tic disorders

关 键 词：抽动障碍 A族溶血性链球菌抗体 测定 脱氧核糖核酸酶类 

分 类 号：R749.94[医药卫生—神经病学与精神病学]