吡咯-2-硫代甲酰胺的简易合成方法  

Facile Synthetic Method for Pyrrole-2-thiocarboxamide

作　　者：蓝晓步[1] 王尔华[1] 

机构地区：[1]中国药科大学医药化工研究所,江苏南京210009

出　　处：《药学进展》2004年第1期42-43,共2页Progress in Pharmaceutical Sciences

摘　　要：目的 :改进制备吡咯 2 硫代甲酰胺的方法。方法 :以硫氰酸钾、氯甲酸乙酯和吡咯为原料经亲电取代 ,水解等反应合成制备目标产物。结果 :该方法工艺简单 ,后处理方便 ,且产率高 ,反应条件温和。结论Objective:To improve the preparation of Pyrrole-2-thiocarboxamide. Methods:The pyrrole-2-Thio-carboxamide is prepared from elctrophilic substition, and hydrolyzed by reacting with potassium thiocyanate, ethyl chloroformate and pyrrole by using suitable method of aftertreament. Results:This method is simple and convenient. The yield is better than that reported before, and the reacting condition is moderate. Conclusion:This synthesis route is practical and easy to popularize in industry.

关 键 词：吡咯-2-硫代甲酰胺 异硫氰基甲酸乙酯 合成 工业化生产 

分 类 号：R914[医药卫生—药物化学]