骨髓活检与涂片同步观察对诊断慢性淋巴细胞白血病的探讨  

Synchronism observation on bone marrow biopsy and bone marrow smear in chronic lymphocytic leukemia

作　　者：赵晓兵[1] 欧英贤[1] 王存邦[1] 陆井之[1] 吕桂玲[1] 

机构地区：[1]兰州军区兰州总医院血液科,兰州730050

出　　处：《临床血液学杂志》2004年第1期14-15,共2页Journal of Clinical Hematology

摘　　要：目的 :探讨骨髓活检和骨髓涂片同步观察在慢性淋巴细胞白血病 (CLL)诊断方面的重要性。方法 :针对 2 0例CLL患者 ,采用骨髓抽吸 活检双标本一步法取材 ,同时观察其骨髓涂片和活检塑料包埋切片。结果 :①骨髓活检切片增生度检出率为 10 0 % ,骨髓涂片检出率为 70 % ,两者差异有显著性意义 (P <0 .0 5 ) ;②切片中原始和幼稚淋巴细胞百分率略高于涂片 ;③ 85 %CLL患者伴有网状纤维增高 ,5 %CLL患者有胶原纤维增高。结论 :同步观察比常规涂片形态学观察的检出率、准确率均明显增高。Objective: Study the value of bone marrow biopsy and bone marrow smear in chronic lymphocytic leukemia. Method: In this article we researched 20 patients with chronic lymphocytic leukemia by using the method of bone marrow biopsy and bone marrow smear. At the same time, we observed those smears and sections. Result: ①the positive ratio of hyperplassa in marrow section is 100%, the positive ratio of marrow smear hyperplastic degree is 70%, obvions difference exists between them (P< 0.05 ); ②the percentage of lymphoblast and prolymphocyte in section is higher than that of smear. ③reticular fibrires increased in 85% chronic lymphocytic leukemia patients,while collagen fibres increuses in 5% chronic lymphocytic leukemia patients. Conclusion: Synchronism observation can increuses the relevant rate and accuracy compared to general smear observation.

关 键 词：慢性淋巴细胞白血病 骨髓涂片 骨髓活检塑料包埋切片 诊断 

分 类 号：R733.72[医药卫生—肿瘤]