不同时间再次化疗对裸鼠移植瘤的作用差异的研究  

Study on Difference of Effect of Chemotherapy Correlated with Time Interval on Transplanted Tumor in Nude Mice

作　　者：刘芹[1] 路平[1] 申素芳[1] 华彩虹[1] 

机构地区：[1]新乡医学院第一附属医院妇产科,河南卫辉453100

出　　处：《中国误诊学杂志》2003年第11期1638-1639,共2页Chinese Journal of Misdiagnostics

基　　金：河南省科技攻关项目(项目编号0224630098)

摘　　要：目的:探索当化疗药物对肿瘤的抑制达到一定程度后,残存细胞的增殖规律,回答在何时再次加入药物能取得最大杀伤效果。方法:实验中将移植瘤裸鼠随机分为4组,各组分别于初次给药后第7天、第14天及第21天再次加入顺铂,观察药物对裸鼠移植瘤的作用差异。结果:各组结果的差异均有显著性(P<0.01)。结论:缩短化疗周期可取得更好的化疗效果。Objective:To seek optimum time interval after chemotherapy for ovarian cancer in vivo. Methods:Human ovarian cancer transplated in the omentum of nude mice model was establisted, then divided into four groups control group, group 1, group 2, and group 3. 0. 25mg CDDP was injected i. p. 7th day, 14th day,and 21th day after initial injection in each group .respectively. The weight of tumors were examined and compared respectively. Results; The differences of weight between each two groups were significant (P<0. 01). Conclusion; Shorten the time interval of chemotherapy could get better effect.

关 键 词：卵巢肿瘤 肿瘤移植 小鼠 近交BALBC 顺铂 化学治疗 

分 类 号：R737.31[医药卫生—肿瘤]