胶质瘤中PTEN、FAK与Ki67表达的研究  

The expression of PTEN . FAK and Ki67 in human gliomas.

作　　者：王虎[1] 浦佩玉[1] 李捷[1] 王春艳[1] 董伦[1] 焦德让 康春生[1] 王广秀[1] 

机构地区：[1]天津医科大学总医院神经外科,天津300052 [2]天泽市脑系科中心医院

出　　处：《中国神经精神疾病杂志》2003年第6期418-420,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金(编号:39970338)资助

摘　　要：目的 探讨PTEN、FAK与Ki67在胶质瘤增殖、侵袭过程中的相互作用。方法 应用SP免疫组化法检测了50例不同级别胶质瘤中的三种蛋白表达情况。结果 不同级别的胶质瘤中PTEN、FAK与Ki67的表达水平不同,Ⅱ级与Ⅲ、Ⅳ级肿瘤之间三者表达差异显著;PTEN与FAK、Ki67在胶质瘤中的表达呈负相关。结论提示PTEN表达缺失可引起FAK及Ki67的过表达,从而加强胶质瘤的增殖和侵袭。Objective To study the interaction of PTEN, FAK and Ki67 in the proliferation and invasion of human gliomas.Methods The SP immunohistochemical method is used to measure the expression of those proteins in 50 gliomas with different grades.Results Expressions of these proteins are varied among different malignancy grading of gliomas. The differences of expression level among grade Ⅱ , grade Ⅲ and Ⅳ were statistically significant; PTEN expression was negatively correlated with the expression of Ki67 and FAK. Conclusions Inactivation of PTEN will lead to the overexpression of Ki67 and FAK, and promotes the prolieration and invasion of gliomas.

关 键 词：胶质瘤 PTEN FAK KI67 细胞增殖 肿瘤侵袭 肿瘤细胞 抑癌基因 粘着斑激酶 

分 类 号：R73-3[医药卫生—肿瘤]