利培酮对女性精神分裂症患者神经内分泌的影响  

Neuroendocrine response in female schizophrenic patients treated with risperidone.

作　　者：于靖[1] 王传跃[1] 林守清[2] 翟屹民[1] 刘瑞玫[1] 陈学红[1] 翁永振[2] 

机构地区：[1]首都医科大学附属北京安定医院二科,北京100088 [2]中国医学科学院中国协和医科大学北京协和医院妇科

出　　处：《中国神经精神疾病杂志》2003年第6期445-447,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：北京卫生扶持学科基金[(1999)卫科扶字10号];首都医学发展科研基金(编号:ZD199816)资助

摘　　要：目的 探讨利培酮对女性精神分裂症患者神经内分泌的影响。方法 对58例女性精神分裂症患者存利培酮治疗至少6个月后,检测性激素水平及利培酮血药浓度。并与30名健康女性进行对照分析。结果 研究组催乳素(PRL)、睾酮水平均显著高于对照组(P<0.01),而雌二醇、孕酮水平则显著低于对照组(P<0.01)。溢乳组PRL水平显著高于无溢乳组(P<0.01),ROC曲线显示,当PRL≥98.0μg/L时溢乳的危险性升高。结论 ①利培酮治疗后可见血催乳素、睾酮水平升高,雌二醇、孕酮水平降低;②催乳素≥98.0μg/L时发生溢乳的危险性升高。探讨利培酮对神经内分泌的影响还需进一步做前瞻性研究。Objective To explore [he effects of risperidone on the neuroendocrine in schizophrenic women. Methods 58 schizophrenic female patients aged 18 to 43 years old treated with risperidone alone for at least 6 months, were involved in a cross-sectional study. Serum hormone levels and serum concentration of fisperidone were examined. 30 healthy women were enrolled in the control group. Results Both the serum prolactin and testosteone levels of the study group were significantly higher than that of the control group ( P < 0.01). On the other hand, both the estradiol and progesterone levels were significantly lower than that of the control group ( P < 0.01). The prolactin level of patients with galaetorrhea was significantly higher than that of those patients without galaetorrhea (P <0,01). Besides the ROC curve showed that as the serium prolactine lever≥98.0 μg/L, the risk of galaetorrhea increased. Conclusions (1)The serum prolactin and testosteone levels may be increased while the estradiol and progesterone levels may be decreased. (2)The risk of galaetorrhea may be markedly increased when the serum prolactine level ≥98.0μg/L. In conclusion, a prospective study is necessary to evaluate the effects of risperidone on neuroendocrine.

关 键 词：利培酮 女性 精神分裂症 神经内分泌 性激素 血药浓度 催乳素 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]