多塞平加氟桂利嗪治疗难治性肠易激综合征(英文)  

Doxepin combined with flunarizine in the treatment of intractable irritable bowel syndrome

作　　者：陈中和[1] 

机构地区：[1]广东省四会市人民医院,526200

出　　处：《中国现代医学杂志》2003年第23期60-62,共3页China Journal of Modern Medicine

摘　　要：目的　评价多塞平加氟桂利嗪治疗难治性肠易激综合征 (IBS)的疗效。方法　采用自身对照研究 ,4 6例非便秘型难治性IBS患者 ,予多塞平 12 .5mg ,bid或 2 5mg ,qn ,氟桂利嗪 5mg ,qn ,口服治疗 4周 ,通过比较患者治疗前后症状积分及减分率的变化评价疗效。结果　 5项主要相关症状积分均在治疗后显著性降低 (P <0 .0 0 1) ,总有效率为 76 .1%。结论　多塞平与氟桂利嗪联合治疗难治性IBS有良好疗效。Objective:To evaluate the curative effect of doxepin combined with fiunarizine on treating intractable irritable bowel syndrome(IBS).Methods:46 patients with non-constipation intractable IBS were administrated for auto-control investigation for four weeks by taking doxepin 12.5?mg bid or 25?mg qn and fiunarizine 5?mg qn orally. Curative effect was evaluated by comparing the symptom scores and effective rate of the cases before the treatment with those after the treatment.Results:The symptom scores after the treatment were significantly lower than those before treatment.The effective rate was 76.1%.Conclusion:Doxepin combined with flunarizine is a more effective treating program for intractable IBS.

关 键 词：肠易激综合征 多塞平 氟桂利嗪 药物治疗 

分 类 号：R574.4[医药卫生—消化系统]