3-甲基-1-(2-(1-哌啶基)苯基)丁基胺的合成  

Synthesis of 3-methyl-1-(2-(1-piperidiny) phenyl)-butylamine

作　　者：侯瑞珍[1] 李秋先[1] 

机构地区：[1]长春工业大学化学工程学院,吉林长春130012

出　　处：《吉林化工学院学报》2003年第4期30-31,共2页Journal of Jilin Institute of Chemical Technology

摘　　要：以3-甲基-1(2-哌啶基苯基)丁基酮为原料,采用Leuckart反应合成3-甲基-1.(2-(1-哌啶基)苯基) 丁基胺,最终化合物经核磁共振氢谱及碳谱得到确证.The 3-methyl-1-(2-(1-piperidiny) phenyl)-butylamine is the key intermediate of Repaglinide. It was synthesized from 3-methyl-1-(2-piperidiny) phenyl)-butylketone through Leuckart reaction. Because the route did not require high pressure, the process was simple and safety. The total yield was 30% . The structures of the intermediate and the target molecule were confirmed by 1H NMR and 13CNMR spectrum.

关 键 词：3-甲基-1-(2-(1-哌啶基)苯基)丁基胺 合成 3-甲基-1(2-哌啶基苯基)丁基酮 Leuckart反应 核磁共振氢谱 核磁共振碳谱 

分 类 号：TQ246.31[化学工程—有机化工]