支气管动脉灌注化疗治疗肺癌的临床研究  

Clinical research of selective bronchial artery infusion and chemotherapy of lung cancer

作　　者：万毅新[1] 王晓平[1] 郑宁[1] 石军年[1] 

机构地区：[1]兰州医学院第二附属医院呼吸科,730030

出　　处：《中国肺癌杂志》2003年第5期378-380,共3页Chinese Journal of Lung Cancer

基　　金：甘肃省自然科学基金资助 (ZS0 0 1 A2 5 0 71 Y)~~

摘　　要：目的　探讨支气管动脉灌注化疗 (BAI)对中晚期肺癌的疗效及影响因素。方法　对 45例中晚期肺癌进行BAI治疗 ,与同期接受全身化疗的 40例中晚期肺癌进行比较。结果　除开 1例大细胞肺癌 ,BAI组完全缓解 (CR) 15例 ( 3 4.1% ) ,部分缓解 (PR) 18例 ( 4 0 .9% ) ,缓解 (CR +PR) 3 3例 ,缓解率 75 .0 % ,与全身化疗之间的疗效 ( 5 0 .0 % )有显著性差异 ,前者优于后者 (P <0 .0 5 ) ,前者毒副反应亦少于后者 (P <0 .0 5 ) ,但BAI组有 1例灌注后截瘫。在BAI组中 ,小细胞未分化癌、鳞癌、腺癌的缓解率分别为 94.5 %、66.6%、40 .0 %。BAI组鳞癌和腺癌的缓解率显著高于全身化疗组 (P <0 .0 5 )。结论　BAI的疗效优于全身静脉化疗 ,且毒副反应低。鳞癌首选BAI治疗 ,小细胞未分化癌以全身化疗为基础 ,辅助应用BAI治疗 ,腺癌可先行BAI治疗 。Objective To study the effect of selective bronchial artery infusion (BAI) and chemotherapy in the treatment of patients with intermediate and advanced lung cancer. Methods Forty five cases of advanced lung cancer were treated by BAI, which were compared with 40 cases of advanced lung cancer treated by systemic chemotherapy. Results The response rate of BAI (33/44, 75.0%) was better than that of systemic chemotherapy (20/40, 50.0%)( P <0.05). The side effect of BAI was lower than that of systemic chemotherapy ( P <0.05), but one case occured paraplegia after BAI. The response rate of small cell undifferentiated lung cancer, squamous cell carcinoma and adenocarcinoma was 94.5% (17/18), 66.6% (14/21) and 40.0% (2/5) respectively in the BAI group. Significant difference of the response rate was found in squamous cell carcinoma and adenocarcinoma between the two groups ( P <0.05).Conclusion BAI has better response rate and less toxicity than systemic chemotherapy in intermediate and advanced lung cancer, especially in patients with squamous cell carcinoma. Small cell undifferentiated lung carcinoma should be treated by systemic chemotherapy firstly and then BAI. Adenocarcinoma should be treated by BAI firstly and then other therapy.

关 键 词：支气管动脉灌注化疗 肺癌 治疗 BAI 临床资料 手术 

分 类 号：R734.2[医药卫生—肿瘤]