联合检测肿瘤标志物在肺癌诊断中的价值  

Diagnostic Significance of Combined Detention of Multiple Tumour Mark ers in Lung Cancer

作　　者：陈燕明[1] 裘建明[1] 

机构地区：[1]苏州市第四人民医院呼吸科,江苏苏州215001

出　　处：《苏州大学学报（医学版）》2003年第6期689-691,共3页Suzhou University Journal of Medical Science

摘　　要：目的　探讨联合检测血清多项肿瘤标志物对肺癌的诊断价值。方法　应用酶联免疫法 (ELISA )检测 86例肺癌、3 0名良性肺病患者和 3 0例健康人的血清CEA、CA12 5、CA 19-9和CA15-3水平。结果　 4项指标在不同组织类型肺癌中均有不同程度升高且明显高于良性肺病组和健康对照组 (P <0 .0 5) ;CEA、CA12 5、CA19-9和CA15-3单检 (总 )的阳性率分别为 41.9%、3 7.2 %、48.9%和 3 6% ,联检 (总 )的阳性率为 94.2 %。结论　 4项指标对不同组织类型肺癌均有一定的诊断价值 。Objective To explore the diagnostic value of combined detection of multiple markers in the determination of lung cancer.Method s Using enzyne_linked immunosorbent assay(ELISA),the serum CEA、CA19-9 、CA125、CA15-3 was determined in eighty_six lung cancer patients、thirty benign lung diseace patients and thirty healthy persons.Results Serum concentrations of CEA、CA19-9、CA125 and CA15-3 were significantly higher in pa tents with lung cancer than that in the patients with bengun lung disease patien ts and healthy persons.The single test sensitivity of CEA、CA19-9、CA125 and CA1 5-3 for diagnosis of lung cancer is 41.9%、37.2%、48.9%、36% respectively;the co mbined test sensitivity is 94.2%.Conclusions Assessing several tumour markers can help differentiating various histological type of lung cancer and increase the sensitivity.

关 键 词：肺癌CEA CAL25 CAL9-9 CAL5-3 诊断 

分 类 号：R734.204[医药卫生—肿瘤]