肺癌中E钙粘蛋白的表达与微血管密度的关系及意义  

Relationship between the expression of E-cadherin and MVD and its significance in lung cancer

作　　者：王新允[1] 杨菊红[1] 马莹[1] 程波[1] 郑宏伟[1] 郑海燕[1] 朱丛中[1] 刘婷[1] 李艳[1] 

机构地区：[1]天津医科大学病理教研室,300070

出　　处：《中国肺癌杂志》2003年第6期477-479,共3页Chinese Journal of Lung Cancer

摘　　要：目的　探讨肺癌中E钙粘蛋白的表达和微血管密度的关系及意义。方法　用SP免疫组化技术检测E钙粘蛋白和Ⅷ因子在 10 4例肺癌组织中的表达 ,利用图像分析系统计算微血管密度。结果　E钙粘蛋白与肺癌分级有密切关系 ,随分化程度的降低 ,E钙粘蛋白的阳性率明显下降 (P <0 .0 5 ) ,而且呈现异常表达。E钙粘蛋白表达还与肺癌组织微血管密度呈显著负相关 (P =0 .0 47)。结论　E钙粘蛋白表达的降低和微血管密度的增加可能在促进肺癌的浸润转移中起重要作用。Objective To study the relationship between the expression of E-cadherin and MVD in lung cancer and its significance. Methods The expressions of E-cadherin and factor Ⅷ were detected in 104 lung cancer tissues by immunohistochemical method, and MVD was calculated by image analysis system. Results The expression of E-cadherin was significantly related to the differentiation of lung cancer (P<0.05). A negative correlation was observed between E-cadherin expression and MVD in lung cancer tissues (P= 0.047). Conclusion Downexpression of E-cadherin and increase of MVD may play an important role in the invasion and metastasis of lung cancer, and may also be used as a useful marker for tumor prognosis.

关 键 词：肺癌 E钙粘蛋白 微血管密度 基因表达 肿瘤 细胞外基质 ECM 

分 类 号：R734.2[医药卫生—肿瘤]