养正消积胶囊联合化疗治疗非小细胞肺癌疗效观察  

Therapeutic effect of Yangzheng Xiaoji Capsule combined with chemotherapy on non-small cell lung cancer

作　　者：彭林 王静宇 张小陆 张洁 张洪珍 PENG Lin;WANG Jingyu;ZHANG Xiaolu;ZHANG Jie;ZHANG Hongzhen(Hebei General Hospital,North China University of Technology,Shijiazhuang 050061,Hebei,China)

机构地区：[1]华北理工大学附属河北省人民医院,河北石家庄050061

出　　处：《现代中西医结合杂志》2019年第9期941-944,984,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨养正消积胶囊辅助应用于非小细胞肺癌化疗的临床疗效。方法选择接受化疗的初治非小细胞肺癌患者78例,根据患者意愿分为观察组和对照组各39例。2组均给予常规化疗,以21 d为1个化疗周期,均完成4个周期化疗。观察组同时在常规化疗基础上给予养正消积胶囊口服6周以上。观察比较2组化疗结束后临床疗效、生活质量(KPS评分)、体质量及化疗毒副反应(消化道反应及血液毒性反应)。结果 2组近期疗效比较差异无统计学意义(P>0.05);观察组KPS评分升高和体质量增加比例均明显高于对照组(P均<0.05),而重度消化道反应和血液毒性反应发生率均明显低于对照组(P均<0.05)。结论养正消积胶囊辅助用于非小细胞肺癌的一线化疗方案未能提高化疗疗效,但可明显改善患者化疗后体质量下降,减轻消化道反应和血液毒性反应,提高患者生活质量。Objective It is to explore the clinical efficacy of Yangzheng Xiaoji Capsule in the treatment of non-small cell lung cancer chemotherapy. Methods 78 patients with newly diagnosed non-small cell lung cancer who received chemotherapy were divided into observation group and control group according to the patient’s wishes. Both groups were given conventional chemotherapy, 21 days as a chemotherapy cycle, and 4 cycles of chemotherapy were completed. The observation group was treated with Yangzheng Xiaoji Capsule for more than 6 weeks on the basis of conventional chemotherapy. The clinical efficacy, quality of life(KPS score), body mass and chemotherapy side effects(digestive tract reaction and hematological toxicity) of the two groups after chemotherapy were observed and compared. Results There was no significant difference in the short-term efficacy between the two groups(P>0.05). The proportion of increase of KPS score and body mass in the observation group were significantly higher than those in the control group(P<0.05), but the incidence of severe gastrointestinal reaction and hematological toxicity reaction was significantly lower than that of the control group(P<0.05). Conclusion Yangzheng Xiaoji Capsule has not improved the efficacy of chemotherapy in the first-line chemotherapy for non-small cell lung cancer, but it can significantly improve the body weight loss after chemotherapy, reduce the digestive tract reaction and blood toxicity, and improve the quality of life of patients.

关 键 词：养正消积胶囊 非小细胞肺癌 化疗 

分 类 号：R734.2[医药卫生—肿瘤]