影像学检查和血清肿瘤标志物检测对肺癌诊断及病理分型的价值  

Imaging Study and Serum Tumor Markers: Their Value in the Diagnosis and Pathologic Classification of Pulmonary Carcinoma

作　　者：刘雨成[1] 孙西军[1] 徐春玲[1] 何银[1] 田岳华[1] 何遂[1] 刘永保[1] 刘淑华[2] 刘海红[2] 

机构地区：[1]江苏省连云港市第一人民医院影像科,222002 [2]江苏省连云港市第一人民医院肿瘤实验室,222002

出　　处：《临床放射学杂志》2003年第11期924-926,共3页Journal of Clinical Radiology

摘　　要：目的　探讨几种常用肿瘤标记物CEA、NSE、LTA检测与影像学诊断对肺癌的检查及病理分型相关研究。资料与方法　选择 190例肺部病变的患者 ,均摄胸部X线平片和CT扫描及肿瘤标记物CEA、NSE、LTA外周血清检测。结果　 (1)CT诊断鳞癌 5 0例、腺癌 4 6例、小细胞性未分化癌 14例、良性病变 2 0例、未定型 6 0例。 (2 )三项肿瘤标记物检测水平及敏感性鳞癌LTA为 85 .3% ,腺癌CEA为 86 .9% ,小细胞未分化癌NSE为 93.3%。 (3)影像学诊断与肿瘤标记物相结合 ,定性诊断及病理分型上升率鳞癌为 14 .7% ,腺癌 11.5 % ,小细胞未分化癌为 4 6 .7%。结论　影像学检查与几种常见肿瘤标记物检测结合在肺癌的诊断、病理分型及良恶性病变的鉴别起着重要的作用 。Objective To evaluate several common tumor markers (CEA, NSE, LTA) and imaging exam in the diagnosis and pathologic classification of pulmonary carcinoma.Materials and Methods Plain chest film, CT scanning were taken and peripheral blood CEA, NSE and LTA were estimated in 190 patients with pulmonary lesions. The results were analyzed.Results (1) CT diagnosed 50 cases of squamous cell carcinoma, 46 cases of adenocarcinoma, 14 cases of small cell lung cancer, 20 cases of benign pulmonary lesions and 60 cases of unclassified tumors. (2) The sensitivity of CEA, NSE and LTA for squamous, adenomous and undifferentiated carcinoma was 85.3%, 86.9% and 93.3%, respectively. (3) The qualitative and pathologic classification correctness for squamous, adenomous and undifferentiated carcinoma was respectively 14.7%, 11.5% and 46.7% when combined imaging features with tumor marker results.Conclusion A combination of imaging manifestations with common tumor markers estimation is of great importance in the diagnosis, differentiation and pathologic classification of pulmonary carcinomas.

关 键 词：影像学检查 血清检测 肿瘤标志物 肺癌 诊断 病理分型 

分 类 号：R734.2[医药卫生—肿瘤] R730.4[医药卫生—临床医学]