亲细胞非均质分子脂质对鼠脑胶质瘤局部治疗的研究  

The Inhibitory Effect of Local Infected CHML to Intracranial Glioma in Rat

作　　者：顾宇翔[1] 陈衔城[1] 徐宏志[1] 王宇倩[1] 

机构地区：[1]复旦大学附属华山医院神经外科,200040

出　　处：《中国临床神经科学》2003年第4期367-369,共3页Chinese Journal of Clinical Neurosciences

摘　　要：目的:探讨亲细胞非均质分子脂质(CHML)对脑胶质瘤动物模型瘤内局部用药的效果。方法:建立SD大鼠脑内C6胶质细胞瘤模型,应用立体定向技术瘤内局部注射CHML-6.0浓度为500和200μg·mL^(-1)的CHML复合液,观察生存状态、饮食状况、体重变化、肢体活动情况及对刺激的反应,行鼠脑MRI和病理学检查以检测药物的疗效。结果:用药后,大鼠的摄食活动等生存状态保持正常,用药组的肿瘤生长受到抑制,其生存期明显高于对照组(P<0.05)。两种浓度组间无显著差别。结论:CHML-6.0浓度为500、200μg·mL^(-1)的CHML复合液瘤内局部治疗脑胶质瘤细胞安全有效。Aim: To study the inhibition of local infection CHML to intracranial glioma in rats. Methods: The C6 glioma model in rat was established for intratumoral chemotherapy with CHML of 500,200αg·mL-1 concentration by stereotactic operation. The effect of CHML was observed by living condition,feeding, weight , activity,response to stimulation, MRI scanning and histological examination. Results:The rat could remain normal state after treatment and the growth of tumor were inhibited apparedtly in CHML groups which has been testified by MRI scan of rat brain and histological examination. The group of intratumor chemotherapy with CHML resulted in a significant longer survival time in the C6 glioma rat model, compared with Ⅲ group treated with 5% GNS and Ⅳ controlled group ( P < 0.05). There was no apparent difference between CHML of 500,200αg·mL-1 concentration groups. Conclusion:It was safe and effective for CHML of 500,200αg·mL-1 concentration to treat the C6 glioma in rat.

关 键 词：亲细胞非均质分子脂质 鼠 脑胶质瘤 药物治疗 瘤内局部用药 动物模型 

分 类 号：R739.41[医药卫生—肿瘤] R73-36[医药卫生—临床医学]