戊四氮点燃猫癫癎形成过程中行为和脑电的动态研究  

Dynamic Study of Electrophysiology and Behavior of the Pentylenetetrazol Kindling cats

作　　者：王开颜[1] 吕传真[1] 洪震[1] 朱国行[1] 王晋阳[1] 

机构地区：[1]复旦大学附属华山医院神经科,200040

出　　处：《中国临床神经科学》2003年第4期370-372,共3页Chinese Journal of Clinical Neurosciences

基　　金：中国博士后科学基金(2003033279)

摘　　要：目的:观察戊四氮点燃猫癫癎形成过程中行为和脑电特征。方法:用低于急性致惊厥剂量的戊四氮(PIZ,25 mg·kg^1)给成年雄性猫每日肌肉注射,观察脑电活动和行为特征。结果:1周后,猫出现发作性面部抽搐,脑电为不对称近额部的散发性棘波,基本节律存在;2周后出现节律性点头,脑电为双侧对称性广泛的散发性棘慢波;16 d后出现发作性四肢强直,脑电活动背景节律变慢,棘慢波呈现阵发性;20 d后出现持续半小时以上的全面性强直阵挛发作,脑电活动为较多不规则的θ和δ波,棘慢波持续时间明显延长。结论:PTZ点燃猫癫癎形成过程中,其行为和脑电阶段性变化明显,与人类癫癎的局灶性继发全面性发作癫癎表现相似。Aim: In order to explore epileptogenesis and its interfering factors, we made a pentylenetertrazol-kindling cat of epileptic model. Methods: Pentylenetetrazol (PTZ 25 mg·kg-1 muscular injection im, daily) was used to kindle male adult cats. The behavior of cats was observed every day for three hours, and EEG under the anesthesia by ketamine hydrochloride (25 mg·kg-1, im) was carried out once a week. Results: The progressive behavior stages of kindling were respectively recorded while using PTZ at lweek,2 week, 16th days and 20th days,ipsilateral or bilateral facial contraction, head vertical movements, generalized myoclonias of the four limbs, and generalized tonic-clonic convulsive seizures. The EEC of respective stage of kindling was asymmetric sporadic spike of forehead, symmetric raulti-spike-wave, sharp wave with slow rhythm, more unregular 8 wave and S wave with paroxysmal spike wave. Conclusion: Our results demonstrated that the epileptic model of PTZ-kindling cat is a good epileptic model with typica EEG and seizure representation at different stage of kindling. The behovior and EEg of this model is more similar to human focal seizure with secondary generalized tonic clonic epilepsy.

关 键 词：戊四氮 猫 癫痫 形成过程 行为特征 脑电特征 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R-33[医药卫生—临床医学]