实验性形觉剥夺性近视晶状体悬韧带的超微结构改变  

Ultrastructure changes of lens zonule in experimental myopia induced by eye lid suture

作　　者：周浩[1] 褚仁远[2] 周行涛[2] 戴锦晖[2] 陈冬红[2] 

机构地区：[1]第二军医大学长征医院眼科,上海200003 [2]复旦大学附属眼耳鼻喉科医院,上海200031

出　　处：《第二军医大学学报》2003年第12期1347-1348,共2页Academic Journal of Second Military Medical University

基　　金：国家教育部博士点重点基金(20020246081)

摘　　要：目的:观察实验性近视中悬韧带超微结构的改变。方法:应用睑裂缝合法制备豚鼠的实验性近视模型,电镜观察悬韧带结构的改变。结果:睑裂缝合眼与对照眼眼轴长度和屈光度都有明显差异(P<0.01)。在实验性近视中,睫状体非色素上皮表面的细小悬韧带纤维的数量明显减少,悬韧带本体中微纤维排列稀疏,同时深入晶状体囊膜悬韧带微纤维明显减少。结论:在近视眼的病理改变中也伴随着悬韧带结构的改变。Objective:To observe the lens zonule infrastructure changes in experimental myopia. Methods; The eye lids were sutured to induce the myopia in guinea pigs and the zonule ultrastructure changes were observed. Results: There were significant differences in the eye axial length and diopter between lid-sutured eyes and controls(P<0. 01). In experimental myopia, the number of tiny fibrils on the surface of non-pigmented epithelium was decreased. The microfibrils in the zonule became sparse and the microfibrils deep in the capsule became less in myopic eyes. Conclusion; Pathological process of myopia is often accompanied with the zonule ultrastructure alternations.

关 键 词：实验 形觉剥夺性近视 晶状体 悬韧带 超微结构 豚鼠 

分 类 号：R778.11[医药卫生—眼科] R-33[医药卫生—临床医学]