肝豆状核变性患者肝纤维化程度与临床分型及B超声像图分型的关系  

The relations between the degree hepatic fibrosis and clinical type,B-ultrasonic wave type in patients with hepatohenticular degeneration

作　　者：丛时兵[1] 洪铭范[1] 韩咏竹[1] 

机构地区：[1]安徽中医学院神经病学研究所

出　　处：《安徽医学》2004年第1期6-8,共3页Anhui Medical Journal

基　　金：安徽省卫生厅第五批科学研究基金 (项目号 :2 0 0 2A0 2 0 )

摘　　要：目的　对不同临床类型的肝豆状核变性 (HLD)患者肝纤维化程度进行评价。方法　对 3 0例健康人及首次入院未经正规驱铜治疗的Wilson型、假性硬化型、肝型各 5 0例共 15 0例患者分别用放射免疫法 (RIA )检测HA、LN、Ⅳ -C、PC -Ⅲ ,酶联免疫吸附法 (ELISA)检测TGF -β1 并进行比较及相关性分析。同时进行肝脏B超声像图分型并将其与肝纤维化血清学指标进行相关性分析。结果　HLD患者肝纤维化指标HA、LN、Ⅳ -C及PC -Ⅲ含量比正常人显著增高 (P <0 .0 0 1) ,TGF -β1 含量比正常人增高 (P =0 .0 2 3 )。HA、LN、Ⅳ -C及PC -Ⅲ血清含量与临床分型呈正相关 ,γ分别为 0 .5 481、0 .43 72、0 .5 44 4及 0 .3 14 6(P均 <0 .0 0 1) ,而TCF -β1 含量与临床分型无相关性 ,γ =0 .0 2 16(P =0 .791)。HA、LN、Ⅳ -C血清含量与B超声像图分型呈正相关 ,γ分别为 0 .3 5 0 4、0 .2 5 65、0 .2 946( (P≤ 0 .0 0 1) ,而PC -Ⅲ及TGF -β1 含量与B超声像图分型无相关性 ,γ分别为 0 .0 2 63、0 .0 12 7(P分别为 0 .747、0 .876)。结论　HLD患者肝纤维化血清学指标显著升高 。Objective To evaluate the degree of hepaticfibrosis of hepatolenticular degeneration(HLD) patients of different clinicaltypes.Methods The author selected 30 healthy control group and 150 HLD patients,including 50 Wilson type, 50 pseudosclerosis type, and 50liver type. The levels of serum HA、LN、Ⅳ-C、PC-Ⅲ and TGF-β 1 of these healthy ones and these HLD patients, who had not been treated with decoper yet, weremeasured respectively by radioimmunoassay(RIA) and TGF-β 1 by enzyme-linked immunosorbent assay(ELISA) and the result of each type was compared and analyzedin correlation with that of other types including those healthy ones. In addition, these 150 patients were observed through B-ultrasonic wave,and the result wasanalyzed in correlation with the five serum index of hepatic fibrosis.Results The levels of serum HA、LN、Ⅳ-C、PC-Ⅲ and TGF-β 1 of HLD patients were notably larger than healthy persons ( P <0.001 or<0.05). The levels of serum HA、LN、Ⅳ-C and PC-Ⅲ were in positive correlationwith clinical types with respective.γ=0.5481,0.4372,0.5444 and 0.3146( P <0.001) and the level of TGF-β 1 was not in correlation with γ=0.0216( P =0.791). The levels of serum HA、LN、Ⅳ-C were in positive correlationwith types byB-ultrasonic wave, and γ=0.3504, 0.2565, 0.2946( P ≤0.001), while the amount of PC-Ⅲ and TGF-β 1 was not in correlation with types by B-ultrasonic wave. And γ=0.0263, 0.0217( P =0.747 and 0.876).Conclusions The serum indeies of all HLD patients are notably higher,which are in positive correlation with clinical types and B-ultrasonicwave types.

关 键 词：肝豆状核变性 肝纤维化 临床分型 B超检查 声像图分型 

分 类 号：R742.4[医药卫生—神经病学与精神病学] R575.2[医药卫生—临床医学]