2,2-双取代-4,6-二氨基-1,2-二氢-1-羟基-s-三嗪类化合物的合成研究  

Synthesis of 2,2-disubstituted-4,6-diamino-1,2-dihydro-s-triazine derivatives

作　　者：毕小玲[1] 钟毅[1] 尤启冬[1] 周伟澄[2] 

机构地区：[1]中国药科大学药物化学教研室,江苏南京210009 [2]上海医药工业研究院,上海200437

出　　处：《华西药学杂志》2003年第6期408-412,共5页West China Journal of Pharmaceutical Sciences

摘　　要：目的　对三嗪类化合物进行合成研究。方法　以盐酸羟胺和苯甲酰氯为原料 ,经酰化、烃化、水解、缩合、环合及脱苄反应合成目的物。结果和结论　共合成了 9个 2 ,2 -双取代 - 4 ,6 -二氨基 - 1,2 -二氢 - 1-羟基 -s -三嗪类化合物 (11-i) ,结构经元素分析、红外吸收光谱、核磁共振氢谱及质谱确证。OBJECTIVE To synthesize triazine derivatives.METHODS The title compounds were synthesized from oxammonium hydrochloride and benzoyl chloride by acylation,alkylation,hydrolysis,condensation,cyclization and debenzylation.RESULTS AND CONCLUSION Nine 2,2-disubstituted-4,6-diamino-1,2-dihydro-s-triazine derivatives,which had not been reported previously,were synthesized.Their structures were confirmed by Elemental analysis,IR spectrum, 1H NMR spectrum and MS spectrum.

关 键 词：抗锥虫药物 三嗪类化合物 合成 盐酸羟胺 苯甲酰氯 

分 类 号：R978.6[医药卫生—药品] R914.5[医药卫生—药学]