3种局部消融方法治疗小鼠移植性肝癌疗效比较  

Comparative study of three local ablation methods for transplanted hepatocellular carcinoma in mice

作　　者：朱伟良[1] 张健[1] 张积仁[1] 汪森明[1] 卜海激[2] 

机构地区：[1]第一军医大学珠江医院肿瘤科,广东广州510282 [2]第一军医大学病理学教研室,广东广州510515

出　　处：《第一军医大学学报》2003年第12期1297-1300,共4页Journal of First Military Medical University

摘　　要：目的观察3种临床常用的局部消融方法治疗小鼠移植性肝癌的疗效,为临床综合治疗不能手术切除的肝癌提供实验依据。方法建立昆明鼠皮下移植性肝癌模型,应用经皮无水乙醇注射治疗(percutaneous ethanol injection therapy,PEIT)、经皮乙酸注射治疗(percutaneous acetic acid injection therapy,PAIT)及经皮局部冷冻治疗(percutaneous local cryosurgery therapy,PLCT)3种局部消融方法治疗,比较其疗效。结果PLCT、PAIT、PEIT治疗抑瘤率分别为99.2%、85.3%和72.8%,治疗后肿瘤完全坏死率分别为100%、60%和40%,生存期分别为(88.11±5.67)、(86.67±7.26)和(72.89±12.86)d。结论PEIT、PAIT或者PLCT均可不同程度抑制小鼠皮下瘤生长,延长生存期,其中PLCT的疗效优于PEIT或PAIT。Objective To observe the effects of three commonly used local ablation methods in the treatment of transplantedhepatocellelur carcinoma in mice to provide experimental evidence for treating hepatocellelur carcinoma that defies surgicalremoval. Methods Mouse models of hepatocellular carcinoma were established by means of subcutaneous transplantation, andtreatment results of the three ablation methods, namely percutaneous ethanol injection therapy (PEIT), percutaneous aceticacid injection therapy (PAIT) and percutaneous local cryosurgery therapy (PLCT), were compared. Results The tumorinhibition rates of PLCT, PAIT and PEIT were 99.2%, 85.3%, and 72.8%, respectively. The rates for complete necrosis of thetumors were 100%(5/5), 60% (3/5), and 40% (2/5), with the survival time of 88.11±5.67, 86.67±7.26, and 72.89±12.86 daysrespectively. Conclusions All of the three local ablation methods can inhibit the tumor growth to various degrees and prolongthe survival time of the tumor-bearing mice. PLCT may yield relatively better result than the other two methods.

关 键 词：局部消融治疗 小鼠 移植性肝癌 经皮乙酸注射 经皮无水乙醇注射 经皮局部冷冻 

分 类 号：R735.7[医药卫生—肿瘤] R73-36[医药卫生—临床医学]