克浊肾舒散治疗大鼠糖尿病肾脏病变的实验研究  

Study of kezhuoshenshusan on renal lesions in diabetic rats

作　　者：胡秀丽 那宇 罗建华 张晓暄 赵波 

机构地区：[1]中国一汽总医院肾内科,长春市130011 [2]上海浦南医院内科,上海市200000

出　　处：《中国厂矿医学》2003年第6期443-444,共2页Chinese Medicine of Factory and Mine

摘　　要：目的 :探讨克浊肾舒散对实验大鼠糖尿病肾脏病变的改善作用机制。方法 :实验大鼠诱发糖尿病肾脏病变 4周后 ,克浊肾舒散给药 10周 ,评价克浊肾舒散对糖尿病大鼠肾脏自由基代谢和非酶糖基化的影响。结果 :克浊肾舒散可以提高糖尿病肾脏病变大鼠肾脏超氧化物歧化酶 (SOD)活性 ,降低肾脏过氧化脂质 (LPO)水平 ,减少肾皮质 5 -羟甲基糖醛 (5 -HMF)释放量和肾小球系膜区硝基四氮唑蓝 (NBT)染色强度。结论 :克浊肾舒散可能通过减轻糖尿病大鼠肾脏自由基代谢紊乱和抑制非酶糖基化反应 ,改善糖尿病大鼠肾脏病变。Objective:To investigate the mechanism of ameliorative effect of Kezhuoshenshusan(KZS) on renal lesions in experimental diabetic rats.Methods:Diabetic rats were brought out renal lesions 4 weeks later,and treated with KZS for 10 weeks,the effect of KZS on renal free radical metabolism and non-enzymatic glycosylation was evaluated.Results:KZS treatment enhanced the renal superoxide dismutase decresed lipid peroxide levels in renal tissue of diabetic rats.After administration of KZS,the liberated 5-hydroxymethyl furfural (5-HMF) from renal cortex and nitroblue tetrazolium (NBT) staining intensity in glomerular mesangial areas were significantly reduced in diabetic rats.Conclusion: Attenuation of free radical metabolism disturbance and inhibition of non-enzymatic glycosylation in kidney may be ameliorate renal lesions in esperimental diabetic rats.

关 键 词：克浊肾舒散 糖尿病 大鼠 自由基 非酶糖基化 作用机制 

分 类 号：R587.1[医药卫生—内分泌] R965[医药卫生—内科学]