高复发率单相抑郁研究  

Analysis of the highly recurrent unipolar disorder

作　　者：徐文炜[1] 陶伟谷[1] 

机构地区：[1]江苏无锡市精神卫生中心,214151

出　　处：《临床精神医学杂志》2003年第6期331-333,共3页Journal of Clinical Psychiatry

摘　　要：目的 :探索高复发率单相抑郁与双相Ⅱ型障碍的关系。　方法 :收集单相抑郁患者 85例和双相Ⅱ型障碍患者 131例 ,其中单相抑郁分为高复发单相组 5 3例和低复发单相组 32例。对 3组的性别、年龄、发病年龄、美国精神障碍诊断与统计手册第 4版轴Ⅰ诊断同病性、精神病性症状、非典型特征、复发次数、一级亲属双相Ⅱ型阳性家族史等临床资料进行对照研究。　结果 :高复发率单相抑郁和双相Ⅱ型障碍的发病年龄、轴Ⅰ诊断同病性和抑郁症慢性化相似 ,而且似乎与复发关系更为密切 ,与双相Ⅱ型障碍阳性家族史的关系则较小。而与低复发单相组的差异较大。　结论 :高复发率单相抑郁可能是位于双相Ⅱ型障碍和低复发率单相抑郁之间的过渡类型 ,其临床特点更接近于双相Ⅱ型障碍。Objective:To determine whether highly recurrent unipolar disorder was related to bipolar Ⅱ disorder. Method:85 consecutive unipolar and 131 consecutive bipolar Ⅱ outpatients were collected.There were three groups in these patients:highly recurrent unipolar,lowly recurrent unipolar and bipolar Ⅱ patients.The three groups were studied by comparing clinic and family history features. Results:Compared with bipolar Ⅱ patients,highly recurrent unipolar patients had significantly fewer atypical features and less family history of bipolar Ⅱ disorder, and had no significant difference in age at onset,axis I comorbidity,and depression chronicity.Conclusion with lowly recurrent unipolar patients,highly recurrent unipolar patients had statistically lower age at onset, more axis I comorbidity, more depression chronicity, and more clinically significant atypical features and more family history of bipolar Ⅱ disorder. Conclusion:Results suggest that highly recurrent unipolar disorder could be midway between bipolar Ⅱ and lowly recurrent unipolar ones.But its clinical features may be similar to bipolar Ⅱ disorder.

关 键 词：心境障碍 复发率 单相抑郁 双相心境障碍 

分 类 号：R749.4[医药卫生—神经病学与精神病学]