儿童孤独症血浆5-羟色胺水平的对照研究  

A comparison of plasma 5-HT in patients with childhood autism and normal controls

作　　者：焦公凯[1] 王伟勇[1] 张志珺[1] 方群[1] 邹冰[1] 王晨阳[1] 金利波[1] 柯晓燕[1] 王民洁[1] 林节[1] 

机构地区：[1]南京医科大学附属脑科医院,210029

出　　处：《临床精神医学杂志》2003年第6期334-335,共2页Journal of Clinical Psychiatry

摘　　要：目的 :通过检测血浆 5 羟色胺 (5 HT)水平 ,初步探讨儿童孤独症的生化病理机制。　方法 :采用放射免疫方法定量检测 5 4例儿童孤独症患儿 (病例组 )及 2 6名健康儿童 (对照组 )的血浆 5 HT水平 ,并作比较。　结果 :病例组的血浆 5 HT水平显著高于对照组 ,但与疾病的严重程度无明显相关。　结论 :提示高 5 HT可能是儿童孤独症生物学标志。Objective:To explore the pathophysiological mechanism of childhood autism determined by the level of plasma serotonin (5-HT). Method:Plasma levels of 5-HT were measured with radiational immunization assay (RIA) in 54 patients with childhood autism and compared with these in 26 healthy controls. Results:Plasma level of 5-HT was significantly higher in autism than in controls. Conclusion:High level of plasma 5-HT may be a kind of biologic index in childhood autism.

关 键 词：儿童孤独症 5—羟色胺 

分 类 号：R749.94[医药卫生—神经病学与精神病学]